Improved pharmacokinetic and pharmacodynamic attributes of artemether–lumefantrine‐loaded solid SMEDDS for oral administration

Objectives To evaluate the in‐vivo efficacy of solid SMEDDS containing combination of artemether and lumefantrine. Methods Formulation development of solid SMEDDS containing combination of artemether and lumefantrine was carried out using spray drying technique. These S‐SMEDDS were evaluated for red...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2017-11, Vol.69 (11), p.1437-1446
Hauptverfasser:	Bhandari, Sameer, Bhandari, Vikram, Sood, Jatin, Jaswal, Sunil, Rana, Vikas, Bedi, Neena, Sehgal, Rakesh, Tiwary, Ashok K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antimalarials - administration & dosage Antimalarials - pharmacokinetics Antimalarials - toxicity Artemether Artemisinins - administration & dosage Artemisinins - pharmacokinetics Artemisinins - toxicity Chemistry, Pharmaceutical Dose-Response Relationship, Drug Drug Combinations Drug Compounding Drug Delivery Systems Drug dosages Drying Emulsions Ethanolamines - administration & dosage Ethanolamines - pharmacokinetics Ethanolamines - toxicity Female Fluorenes - administration & dosage Fluorenes - pharmacokinetics Fluorenes - toxicity Histopathology lumefantrine Male Mice Mortality Oral administration Parasitemia Pharmacodynamics Pharmacokinetics Rats Rats, Wistar Rodents solid SMEDDS Spray drying Subacute toxicity Tablets Toxicity
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