Interferon-[beta] protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase

Interferon-[beta] protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase

Several large clinical trials have demonstrated that interferon-[beta] (IFN-[beta]) therapy is effective in the treatment of multiple sclerosis (MS) patients. However, the mechanisms underlying the beneficial effects of IFN-[beta] are not fully understood. Most of the effort in the study of the rele...

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Veröffentlicht in:Experimental cell research 2008-07, Vol.314 (11-12), p.2231
Hauptverfasser: Barca, Olga, Costoya, José A, Señarís, Rosa M, Arce, Víctor M
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Sprache:eng
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Apoptosis
Cellular biology
Interferon
Kinases
Multiple sclerosis
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container_issue 11-12
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container_title Experimental cell research
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creator Barca, Olga
Costoya, José A
Señarís, Rosa M
Arce, Víctor M
description Several large clinical trials have demonstrated that interferon-[beta] (IFN-[beta]) therapy is effective in the treatment of multiple sclerosis (MS) patients. However, the mechanisms underlying the beneficial effects of IFN-[beta] are not fully understood. Most of the effort in the study of the relevant mechanisms of IFN-[beta] has dealt with its immunomodulatory actions. However, the beneficial effects of IFN-[beta] in MS patients may also depend on non-immune mechanisms, including the modulation of astrocyte function. In the present work, we have found that IFN-[beta] treatment protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase. We propose that this effect may be of importance to protect astrocytes against apoptosis within the demyelinated plaques of the MS. [PUBLICATION ABSTRACT]
doi_str_mv 10.1016/j.yexcr.2008.04.005
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subjects Apoptosis
Cellular biology
Interferon
Kinases
Multiple sclerosis
title Interferon-[beta] protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase
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