HDAC2 deficiency sensitizes colon cancer cells to TNF[alpha]-induced apoptosis through inhibition of NF-[kappa]B activity

HDAC inhibitors exert potent anti-tumorigenic and anti-inflammatory activity. Their effects are selective for transformed cells, and we recently demonstrated that transformation of epithelial cells with k-Ras sensitizes cells to HDACi induced apoptosis. The aim of this study was to determine whether...

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Veröffentlicht in:	Experimental cell research 2008-04, Vol.314 (7), p.1507
Hauptverfasser:	Kaler, Pawan, Sasazuki, Takehiko, Shirasawa, Senji, Augenlicht, Leonard, Klampfer, Lidija
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding sites Cellular biology Colorectal cancer Mutation
Online-Zugang:	Volltext
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