Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities
The biological complexity of NGF action is achieved by binding two distinct neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an in...
Gespeichert in:
Veröffentlicht in: | Experimental cell research 2007-08, Vol.313 (14), p.2980-2992 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2992 |
---|---|
container_issue | 14 |
container_start_page | 2980 |
container_title | Experimental cell research |
container_volume | 313 |
creator | DIOLAITI, D BERNARDONI, R TRAZZI, S PAPA, A PORRO, A BONO, F HERBERT, J PERINI, G DELLAVALLE, G |
description | The biological complexity of NGF action is achieved by binding two distinct neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In this study, we have focused on how p75NTR may affect TrkA downstream signaling with respect to neuronal differentiation. Here, we have shown that cooperation between p75NTR and TrkA results in an increased NGF-mediated TrkA autophosphorylation, leads to a sustained activation of ERK1/2 and accelerates neurite outgrowth. Interestingly, neurite outgrowth is concomitant with a selective enhancement of the AP-1 activity and the transcriptional activation of genes such as GAP-43 and p21(CIP/WAF), known to be involved in the differentiation process. Collectively, our results unveil a functional link between the specific expression profile of neurotrophin receptors in neuronal cells and the NGF-mediated regulation of the differentiation process possibly through a persistent ERKs activation and the selective control of the AP-1 activity. [PUBLICATION ABSTRACT] |
doi_str_mv | 10.1016/j.yexcr.2007.06.002 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_194656331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1315519041</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1871-9161922555e50a75aaf76b5b2a520ef7b72711650564744c136b46b42f8919f53</originalsourceid><addsrcrecordid>eNotkcFqGzEQhkVpoW6aJ-hF9NQedj2jXUm7R2PiJDS0IbjkKLTyqMh1tVtpndQvlWfs2g4MDMN8_z8MP2OfEEoEVPNteaB_LpUCQJegSgDxhs0QWihELcRbNgPAuqgbod-zDzlvAaBpUM3Yy2of3Rj6aHfc9f1AyR4n3tH4TBT5Ov1ecBs3fNDy-_qBW-dod4Qo80j7dBJugveUKI7hVXzgIbpENtOGj8nG7FIYTqve8-vFfVFXZ1OBX5a39_PHxeor_0VxMn0Kll89fMO5OBETi9PRMTyFMVD-yN55u8t0-dov2M_V1Xp5U9z9uL5dLu4Kh43GokWFrRBSSpJgtbTWa9XJTlgpgLzutNCISoJUta5rh5Xq6qmEb1psvawu2Oez75D6v3vKo9n2-zT9mg22tZKqqnCCqjPkUp9zIm-GFP7YdDAI5piL2ZpTLuaYiwFlplyq_y9ugLE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>194656331</pqid></control><display><type>article</type><title>Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities</title><source>Elsevier ScienceDirect Journals Complete</source><creator>DIOLAITI, D ; BERNARDONI, R ; TRAZZI, S ; PAPA, A ; PORRO, A ; BONO, F ; HERBERT, J ; PERINI, G ; DELLAVALLE, G</creator><creatorcontrib>DIOLAITI, D ; BERNARDONI, R ; TRAZZI, S ; PAPA, A ; PORRO, A ; BONO, F ; HERBERT, J ; PERINI, G ; DELLAVALLE, G</creatorcontrib><description>The biological complexity of NGF action is achieved by binding two distinct neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In this study, we have focused on how p75NTR may affect TrkA downstream signaling with respect to neuronal differentiation. Here, we have shown that cooperation between p75NTR and TrkA results in an increased NGF-mediated TrkA autophosphorylation, leads to a sustained activation of ERK1/2 and accelerates neurite outgrowth. Interestingly, neurite outgrowth is concomitant with a selective enhancement of the AP-1 activity and the transcriptional activation of genes such as GAP-43 and p21(CIP/WAF), known to be involved in the differentiation process. Collectively, our results unveil a functional link between the specific expression profile of neurotrophin receptors in neuronal cells and the NGF-mediated regulation of the differentiation process possibly through a persistent ERKs activation and the selective control of the AP-1 activity. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0014-4827</identifier><identifier>EISSN: 1090-2422</identifier><identifier>DOI: 10.1016/j.yexcr.2007.06.002</identifier><language>eng</language><publisher>New York: Elsevier BV</publisher><subject>Cellular biology ; Molecular biology ; Neurons ; Signal transduction</subject><ispartof>Experimental cell research, 2007-08, Vol.313 (14), p.2980-2992</ispartof><rights>Copyright © 2007 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1871-9161922555e50a75aaf76b5b2a520ef7b72711650564744c136b46b42f8919f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>DIOLAITI, D</creatorcontrib><creatorcontrib>BERNARDONI, R</creatorcontrib><creatorcontrib>TRAZZI, S</creatorcontrib><creatorcontrib>PAPA, A</creatorcontrib><creatorcontrib>PORRO, A</creatorcontrib><creatorcontrib>BONO, F</creatorcontrib><creatorcontrib>HERBERT, J</creatorcontrib><creatorcontrib>PERINI, G</creatorcontrib><creatorcontrib>DELLAVALLE, G</creatorcontrib><title>Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities</title><title>Experimental cell research</title><description>The biological complexity of NGF action is achieved by binding two distinct neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In this study, we have focused on how p75NTR may affect TrkA downstream signaling with respect to neuronal differentiation. Here, we have shown that cooperation between p75NTR and TrkA results in an increased NGF-mediated TrkA autophosphorylation, leads to a sustained activation of ERK1/2 and accelerates neurite outgrowth. Interestingly, neurite outgrowth is concomitant with a selective enhancement of the AP-1 activity and the transcriptional activation of genes such as GAP-43 and p21(CIP/WAF), known to be involved in the differentiation process. Collectively, our results unveil a functional link between the specific expression profile of neurotrophin receptors in neuronal cells and the NGF-mediated regulation of the differentiation process possibly through a persistent ERKs activation and the selective control of the AP-1 activity. [PUBLICATION ABSTRACT]</description><subject>Cellular biology</subject><subject>Molecular biology</subject><subject>Neurons</subject><subject>Signal transduction</subject><issn>0014-4827</issn><issn>1090-2422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNotkcFqGzEQhkVpoW6aJ-hF9NQedj2jXUm7R2PiJDS0IbjkKLTyqMh1tVtpndQvlWfs2g4MDMN8_z8MP2OfEEoEVPNteaB_LpUCQJegSgDxhs0QWihELcRbNgPAuqgbod-zDzlvAaBpUM3Yy2of3Rj6aHfc9f1AyR4n3tH4TBT5Ov1ecBs3fNDy-_qBW-dod4Qo80j7dBJugveUKI7hVXzgIbpENtOGj8nG7FIYTqve8-vFfVFXZ1OBX5a39_PHxeor_0VxMn0Kll89fMO5OBETi9PRMTyFMVD-yN55u8t0-dov2M_V1Xp5U9z9uL5dLu4Kh43GokWFrRBSSpJgtbTWa9XJTlgpgLzutNCISoJUta5rh5Xq6qmEb1psvawu2Oez75D6v3vKo9n2-zT9mg22tZKqqnCCqjPkUp9zIm-GFP7YdDAI5piL2ZpTLuaYiwFlplyq_y9ugLE</recordid><startdate>20070815</startdate><enddate>20070815</enddate><creator>DIOLAITI, D</creator><creator>BERNARDONI, R</creator><creator>TRAZZI, S</creator><creator>PAPA, A</creator><creator>PORRO, A</creator><creator>BONO, F</creator><creator>HERBERT, J</creator><creator>PERINI, G</creator><creator>DELLAVALLE, G</creator><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20070815</creationdate><title>Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities</title><author>DIOLAITI, D ; BERNARDONI, R ; TRAZZI, S ; PAPA, A ; PORRO, A ; BONO, F ; HERBERT, J ; PERINI, G ; DELLAVALLE, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1871-9161922555e50a75aaf76b5b2a520ef7b72711650564744c136b46b42f8919f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Cellular biology</topic><topic>Molecular biology</topic><topic>Neurons</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DIOLAITI, D</creatorcontrib><creatorcontrib>BERNARDONI, R</creatorcontrib><creatorcontrib>TRAZZI, S</creatorcontrib><creatorcontrib>PAPA, A</creatorcontrib><creatorcontrib>PORRO, A</creatorcontrib><creatorcontrib>BONO, F</creatorcontrib><creatorcontrib>HERBERT, J</creatorcontrib><creatorcontrib>PERINI, G</creatorcontrib><creatorcontrib>DELLAVALLE, G</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Experimental cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DIOLAITI, D</au><au>BERNARDONI, R</au><au>TRAZZI, S</au><au>PAPA, A</au><au>PORRO, A</au><au>BONO, F</au><au>HERBERT, J</au><au>PERINI, G</au><au>DELLAVALLE, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities</atitle><jtitle>Experimental cell research</jtitle><date>2007-08-15</date><risdate>2007</risdate><volume>313</volume><issue>14</issue><spage>2980</spage><epage>2992</epage><pages>2980-2992</pages><issn>0014-4827</issn><eissn>1090-2422</eissn><abstract>The biological complexity of NGF action is achieved by binding two distinct neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In this study, we have focused on how p75NTR may affect TrkA downstream signaling with respect to neuronal differentiation. Here, we have shown that cooperation between p75NTR and TrkA results in an increased NGF-mediated TrkA autophosphorylation, leads to a sustained activation of ERK1/2 and accelerates neurite outgrowth. Interestingly, neurite outgrowth is concomitant with a selective enhancement of the AP-1 activity and the transcriptional activation of genes such as GAP-43 and p21(CIP/WAF), known to be involved in the differentiation process. Collectively, our results unveil a functional link between the specific expression profile of neurotrophin receptors in neuronal cells and the NGF-mediated regulation of the differentiation process possibly through a persistent ERKs activation and the selective control of the AP-1 activity. [PUBLICATION ABSTRACT]</abstract><cop>New York</cop><pub>Elsevier BV</pub><doi>10.1016/j.yexcr.2007.06.002</doi><tpages>13</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0014-4827 |
ispartof | Experimental cell research, 2007-08, Vol.313 (14), p.2980-2992 |
issn | 0014-4827 1090-2422 |
language | eng |
recordid | cdi_proquest_journals_194656331 |
source | Elsevier ScienceDirect Journals Complete |
subjects | Cellular biology Molecular biology Neurons Signal transduction |
title | Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A14%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20cooperation%20between%20TrkA%20and%20p75NTR%20accelerates%20neuronal%20differentiation%20by%20increased%20transcription%20of%20GAP-43%20and%20p21(CIP/WAF)%20genes%20via%20ERK1/2%20and%20AP-1%20activities&rft.jtitle=Experimental%20cell%20research&rft.au=DIOLAITI,%20D&rft.date=2007-08-15&rft.volume=313&rft.issue=14&rft.spage=2980&rft.epage=2992&rft.pages=2980-2992&rft.issn=0014-4827&rft.eissn=1090-2422&rft_id=info:doi/10.1016/j.yexcr.2007.06.002&rft_dat=%3Cproquest_cross%3E1315519041%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=194656331&rft_id=info:pmid/&rfr_iscdi=true |