NFIA co-localizes with PPAR[gamma] and transcriptionally controls the brown fat gene program

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions....

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Veröffentlicht in:Nature cell biology 2017-09, Vol.19 (9), p.1081
Hauptverfasser: Hiraike, Yuta, Waki, Hironori, Yu, Jing, Nakamura, Masahiro, Miyake, Kana, Nagano, Gaku, Nakaki, Ryo
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Sprache:eng
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