Extracorporeal Life Support: Indications and Use in Severely Poisoned Patients
The primary cause of death in patients with severe poisonings is cardiopulmonary failure. Meticulous supportive care remains the mainstay of treatment. However, early aggressive hemodynamic support with extracorporeal life support (ECLS) can be beneficial in patients with severe refractory toxin-ind...
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| Veröffentlicht in: | Clinical pediatric emergency medicine 2017-09, Vol.18 (3), p.227-232 |
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| container_title | Clinical pediatric emergency medicine |
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| creator | Hughes, Adrienne Johnson, Nicholas J. Mazor, Suzan S. |
| description | The primary cause of death in patients with severe poisonings is cardiopulmonary failure. Meticulous supportive care remains the mainstay of treatment. However, early aggressive hemodynamic support with extracorporeal life support (ECLS) can be beneficial in patients with severe refractory toxin-induced shock. Although ECLS cannot neutralize toxins or facilitate poison removal, it can restore end-organ perfusion until elimination of the toxin and/or end-organ recovery occur. Preferentially, ECLS is used as a “bridge to recovery,” and as such, severe poisoning is perhaps one of the most ideal indications for its use. The aim of this article is to review the history of ECLS and provide an overview of basic physiologic principles, current techniques, indications, contraindications, complications, and its role in the treatment of the severely poisoned patient with refractory cardiovascular collapse. |
| doi_str_mv | 10.1016/j.cpem.2017.07.008 |
| format | Article |
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Meticulous supportive care remains the mainstay of treatment. However, early aggressive hemodynamic support with extracorporeal life support (ECLS) can be beneficial in patients with severe refractory toxin-induced shock. Although ECLS cannot neutralize toxins or facilitate poison removal, it can restore end-organ perfusion until elimination of the toxin and/or end-organ recovery occur. Preferentially, ECLS is used as a “bridge to recovery,” and as such, severe poisoning is perhaps one of the most ideal indications for its use. The aim of this article is to review the history of ECLS and provide an overview of basic physiologic principles, current techniques, indications, contraindications, complications, and its role in the treatment of the severely poisoned patient with refractory cardiovascular collapse.</description><identifier>ISSN: 1522-8401</identifier><identifier>EISSN: 1558-2310</identifier><identifier>DOI: 10.1016/j.cpem.2017.07.008</identifier><language>eng</language><publisher>Maryland Heights: Elsevier Inc</publisher><subject>cardiogenic shock ; Cardiomyopathy ; cardiopulmonary resuscitation ; cardiotoxicity ; Evacuations & rescues ; extracorporeal life support ; Heart ; Intensive care ; Lungs ; Mortality ; Patients ; Perfusion ; Poisoning ; Respiratory distress syndrome ; Respiratory therapy ; Surgical apparatus & instruments ; Swine flu ; toxicology</subject><ispartof>Clinical pediatric emergency medicine, 2017-09, Vol.18 (3), p.227-232</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright Elsevier Limited 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-48618f64994b095b3657a405b385b14399efc1c6e52b7e52462477b5bb7d361a3</citedby><cites>FETCH-LOGICAL-c328t-48618f64994b095b3657a405b385b14399efc1c6e52b7e52462477b5bb7d361a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1522840117300460$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Hughes, Adrienne</creatorcontrib><creatorcontrib>Johnson, Nicholas J.</creatorcontrib><creatorcontrib>Mazor, Suzan S.</creatorcontrib><title>Extracorporeal Life Support: Indications and Use in Severely Poisoned Patients</title><title>Clinical pediatric emergency medicine</title><description>The primary cause of death in patients with severe poisonings is cardiopulmonary failure. Meticulous supportive care remains the mainstay of treatment. However, early aggressive hemodynamic support with extracorporeal life support (ECLS) can be beneficial in patients with severe refractory toxin-induced shock. Although ECLS cannot neutralize toxins or facilitate poison removal, it can restore end-organ perfusion until elimination of the toxin and/or end-organ recovery occur. Preferentially, ECLS is used as a “bridge to recovery,” and as such, severe poisoning is perhaps one of the most ideal indications for its use. The aim of this article is to review the history of ECLS and provide an overview of basic physiologic principles, current techniques, indications, contraindications, complications, and its role in the treatment of the severely poisoned patient with refractory cardiovascular collapse.</description><subject>cardiogenic shock</subject><subject>Cardiomyopathy</subject><subject>cardiopulmonary resuscitation</subject><subject>cardiotoxicity</subject><subject>Evacuations & rescues</subject><subject>extracorporeal life support</subject><subject>Heart</subject><subject>Intensive care</subject><subject>Lungs</subject><subject>Mortality</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Poisoning</subject><subject>Respiratory distress syndrome</subject><subject>Respiratory therapy</subject><subject>Surgical apparatus & instruments</subject><subject>Swine flu</subject><subject>toxicology</subject><issn>1522-8401</issn><issn>1558-2310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UF1LwzAUDaLgnP4BnwI-tyZpkqbii4ypg6GDueeQpreQsTU16Yb796bMZ-Fy77lwzv04CN1TklNC5eM2tz3sc0ZomZMURF2gCRVCZayg5HLEjGWKE3qNbmLcEsIKwdUEfcx_hmCsD70PYHZ46VrA60Of2uEJL7rGWTM430VsugZvImDX4TUcIcDuhFfeRd9Bg1eJBN0Qb9FVa3YR7v7qFG1e51-z92z5-baYvSwzWzA1ZFxJqlrJq4rXpBJ1IUVpOElAiZryoqqgtdRKEKwuU-KS8bKsRV2XTSGpKabo4Ty3D_77AHHQW38IXVqpacWFkpILkVjszLLBxxig1X1wexNOmhI9-qa3evRNj75pkoKoJHo-iyDdf3QQdLTpNwuNC2AH3Xj3n_wXvJR1PA</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Hughes, Adrienne</creator><creator>Johnson, Nicholas J.</creator><creator>Mazor, Suzan S.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170901</creationdate><title>Extracorporeal Life Support: Indications and Use in Severely Poisoned Patients</title><author>Hughes, Adrienne ; Johnson, Nicholas J. ; Mazor, Suzan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-48618f64994b095b3657a405b385b14399efc1c6e52b7e52462477b5bb7d361a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>cardiogenic shock</topic><topic>Cardiomyopathy</topic><topic>cardiopulmonary resuscitation</topic><topic>cardiotoxicity</topic><topic>Evacuations & rescues</topic><topic>extracorporeal life support</topic><topic>Heart</topic><topic>Intensive care</topic><topic>Lungs</topic><topic>Mortality</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Poisoning</topic><topic>Respiratory distress syndrome</topic><topic>Respiratory therapy</topic><topic>Surgical apparatus & instruments</topic><topic>Swine flu</topic><topic>toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, Adrienne</creatorcontrib><creatorcontrib>Johnson, Nicholas J.</creatorcontrib><creatorcontrib>Mazor, Suzan S.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Clinical pediatric emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, Adrienne</au><au>Johnson, Nicholas J.</au><au>Mazor, Suzan S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracorporeal Life Support: Indications and Use in Severely Poisoned Patients</atitle><jtitle>Clinical pediatric emergency medicine</jtitle><date>2017-09-01</date><risdate>2017</risdate><volume>18</volume><issue>3</issue><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>1522-8401</issn><eissn>1558-2310</eissn><abstract>The primary cause of death in patients with severe poisonings is cardiopulmonary failure. Meticulous supportive care remains the mainstay of treatment. However, early aggressive hemodynamic support with extracorporeal life support (ECLS) can be beneficial in patients with severe refractory toxin-induced shock. Although ECLS cannot neutralize toxins or facilitate poison removal, it can restore end-organ perfusion until elimination of the toxin and/or end-organ recovery occur. Preferentially, ECLS is used as a “bridge to recovery,” and as such, severe poisoning is perhaps one of the most ideal indications for its use. The aim of this article is to review the history of ECLS and provide an overview of basic physiologic principles, current techniques, indications, contraindications, complications, and its role in the treatment of the severely poisoned patient with refractory cardiovascular collapse.</abstract><cop>Maryland Heights</cop><pub>Elsevier Inc</pub><doi>10.1016/j.cpem.2017.07.008</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical pediatric emergency medicine, 2017-09, Vol.18 (3), p.227-232 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | cardiogenic shock Cardiomyopathy cardiopulmonary resuscitation cardiotoxicity Evacuations & rescues extracorporeal life support Heart Intensive care Lungs Mortality Patients Perfusion Poisoning Respiratory distress syndrome Respiratory therapy Surgical apparatus & instruments Swine flu toxicology |
| title | Extracorporeal Life Support: Indications and Use in Severely Poisoned Patients |
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