Positive feedback loops of enhanced canonical Wnt confers stemness traits to pancreatic cancer cells
Method: Pathway analysis in vitro was evaluated by RPPA, Western blot, qPCR, Super-TOP/FOP luciferase assays, and cell lines transduced with the lentiviral Super-TOP-GFP reporter construct (7TGC); cancer stemness was monitored by sphere-formation assays (SFA). Conclusion: Our studies reveal adaptive...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-09, Vol.17 (4), p.S32-S32 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
| container_volume | 17 |
| creator | Ilmer, Matthias Wang, Jing Boiles Recio, Alejandro Renz, Bernhard D'haese, Jan Werner, Jens Alt, Eckhard Vykoukal, Jody |
| description | Method: Pathway analysis in vitro was evaluated by RPPA, Western blot, qPCR, Super-TOP/FOP luciferase assays, and cell lines transduced with the lentiviral Super-TOP-GFP reporter construct (7TGC); cancer stemness was monitored by sphere-formation assays (SFA). Conclusion: Our studies reveal adaptive aspects of pancreatic cancer stemness arising from populations of CSCs that misappropriate functional and responsive elements of archetypical self-renewal pathways that might be reinforced by positive feedback loops; disruption of these dynamic CSC processes could present novel therapeutic strategies for patients with PDAC. |
| doi_str_mv | 10.1016/j.pan.2017.07.107 |
| format | Article |
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Conclusion: Our studies reveal adaptive aspects of pancreatic cancer stemness arising from populations of CSCs that misappropriate functional and responsive elements of archetypical self-renewal pathways that might be reinforced by positive feedback loops; disruption of these dynamic CSC processes could present novel therapeutic strategies for patients with PDAC.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2017.07.107</identifier><language>eng</language><publisher>Philadelphia: Elsevier B.V</publisher><subject>Cell self-renewal ; Feedback ; Pancreatic cancer ; Tumors ; Wnt protein</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... 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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2017-09, Vol.17 (4), p.S32-S32 |
| issn | 1424-3903 1424-3911 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Cell self-renewal Feedback Pancreatic cancer Tumors Wnt protein |
| title | Positive feedback loops of enhanced canonical Wnt confers stemness traits to pancreatic cancer cells |
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