Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation
Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreate...
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| Veröffentlicht in: | Molecular neurobiology 2017-11, Vol.54 (9), p.7327-7334 |
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| creator | Shi, Zhe Ren, Huixia Huang, Zhijian Peng, Yu He, Baixuan Yao, Xiaoli Yuan, Ti-Fei Su, Huanxing |
| description | Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression. |
| doi_str_mv | 10.1007/s12035-016-0212-9 |
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N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-016-0212-9</identifier><identifier>PMID: 27815837</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Behavior ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Cytokines ; Depression ; Depression - chemically induced ; Depression - pathology ; Depression - prevention & control ; Disease prevention ; Fish ; Fish oils ; Fish Oils - administration & dosage ; Hypothalamus ; Inflammation ; Inflammation - chemically induced ; Inflammation - pathology ; Inflammation - prevention & control ; Lipopolysaccharides ; Lipopolysaccharides - toxicity ; Male ; Mental depression ; Mental disorders ; Mice ; Mice, Inbred C57BL ; Neurobiology ; Neurology ; Neurosciences ; Oils & fats ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Polyunsaturated fatty acids ; Rodents ; Secretion ; Stress</subject><ispartof>Molecular neurobiology, 2017-11, Vol.54 (9), p.7327-7334</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Molecular Neurobiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-d37031b2f062ae346ae89430c0046539d4eb7b0796452d095e5766d8e792e9f63</citedby><cites>FETCH-LOGICAL-c486t-d37031b2f062ae346ae89430c0046539d4eb7b0796452d095e5766d8e792e9f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-016-0212-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-016-0212-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27815837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Zhe</creatorcontrib><creatorcontrib>Ren, Huixia</creatorcontrib><creatorcontrib>Huang, Zhijian</creatorcontrib><creatorcontrib>Peng, Yu</creatorcontrib><creatorcontrib>He, Baixuan</creatorcontrib><creatorcontrib>Yao, Xiaoli</creatorcontrib><creatorcontrib>Yuan, Ti-Fei</creatorcontrib><creatorcontrib>Su, Huanxing</creatorcontrib><title>Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression.</description><subject>Animals</subject><subject>Behavior</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cytokines</subject><subject>Depression</subject><subject>Depression - chemically induced</subject><subject>Depression - pathology</subject><subject>Depression - prevention & control</subject><subject>Disease prevention</subject><subject>Fish</subject><subject>Fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Hypothalamus</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - pathology</subject><subject>Inflammation - prevention & control</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Male</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oils & fats</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Polyunsaturated fatty acids</subject><subject>Rodents</subject><subject>Secretion</subject><subject>Stress</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtOwzAQRS0EgvL4ADYoEmvD-B0veVOpAhawtpxkQg1tEuykUv-eoAJiw2oWc-690iHkmMEZAzDniXEQigLTFDjj1G6RCVPKUsZyvk0mkFtBjZb5HtlP6Q2AcwZml-xxkzOVCzMheBvSPHsMi-wp4gqbPmWz0LVdu1gnX5ZzH0OFdNpUQ4lVdo1dxJTCCuksvGN2iXO_Cm3MinU2beahCH1oXrMHHGIbmnrhl0vfh7Y5JDu1XyQ8-r4H5OX25vnqns4e76ZXFzNaylz3tBIGBCt4DZp7FFJ7zK0UUAJIrYStJBamAGO1VLwCq1AZrascjeVoay0OyOmmt4vtx4Cpd2_tEJtx0jErpdFCWTZSbEOVsU0pYu26GJY-rh0D9yXWbcS6Uaz7EuvsmDn5bh6KJVa_iR-TI8A3QBpfzSvGP9P_tn4CHiODFA</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Shi, Zhe</creator><creator>Ren, Huixia</creator><creator>Huang, Zhijian</creator><creator>Peng, Yu</creator><creator>He, Baixuan</creator><creator>Yao, Xiaoli</creator><creator>Yuan, Ti-Fei</creator><creator>Su, Huanxing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20171101</creationdate><title>Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation</title><author>Shi, Zhe ; Ren, Huixia ; Huang, Zhijian ; Peng, Yu ; He, Baixuan ; Yao, Xiaoli ; Yuan, Ti-Fei ; Su, Huanxing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-d37031b2f062ae346ae89430c0046539d4eb7b0796452d095e5766d8e792e9f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Cytokines</topic><topic>Depression</topic><topic>Depression - chemically induced</topic><topic>Depression - pathology</topic><topic>Depression - prevention & control</topic><topic>Disease prevention</topic><topic>Fish</topic><topic>Fish oils</topic><topic>Fish Oils - administration & dosage</topic><topic>Hypothalamus</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - pathology</topic><topic>Inflammation - prevention & control</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Male</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oils & fats</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Polyunsaturated fatty acids</topic><topic>Rodents</topic><topic>Secretion</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Zhe</creatorcontrib><creatorcontrib>Ren, Huixia</creatorcontrib><creatorcontrib>Huang, Zhijian</creatorcontrib><creatorcontrib>Peng, Yu</creatorcontrib><creatorcontrib>He, Baixuan</creatorcontrib><creatorcontrib>Yao, Xiaoli</creatorcontrib><creatorcontrib>Yuan, Ti-Fei</creatorcontrib><creatorcontrib>Su, Huanxing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Zhe</au><au>Ren, Huixia</au><au>Huang, Zhijian</au><au>Peng, Yu</au><au>He, Baixuan</au><au>Yao, Xiaoli</au><au>Yuan, Ti-Fei</au><au>Su, Huanxing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>54</volume><issue>9</issue><spage>7327</spage><epage>7334</epage><pages>7327-7334</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Depression is associated with somatic immune changes, and neuroinflammation is now recognized as hallmark for depressive disorders. N-3 (or omega-3) polyunsaturated fatty acids (PUFAs) are well known to suppress neuroinflammation, reduce oxidative stress, and protect neuron from injury. We pretreated animals with fish oil and induced acute depression-like behaviors with systemic lipopolysaccharide (LPS) injection. The levels of cytokines and stress hormones were determined from plasma and different brain areas. The results showed that fish oil treatment prevent LPS-induce depressive behavior by suppression of neuroinflammation. LPS induced acute neuroinflammation in different brain regions, which were prevented in fish oil fed mice. However, neither LPS administration nor fish oil treatment has strong effect on stress hormone secretion in the hypothalamus and adrenal. Fish oil might provide a useful therapy against inflammation-associated depression.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27815837</pmid><doi>10.1007/s12035-016-0212-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Behavior Biomedical and Life Sciences Biomedicine Brain Cell Biology Cytokines Depression Depression - chemically induced Depression - pathology Depression - prevention & control Disease prevention Fish Fish oils Fish Oils - administration & dosage Hypothalamus Inflammation Inflammation - chemically induced Inflammation - pathology Inflammation - prevention & control Lipopolysaccharides Lipopolysaccharides - toxicity Male Mental depression Mental disorders Mice Mice, Inbred C57BL Neurobiology Neurology Neurosciences Oils & fats Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Polyunsaturated fatty acids Rodents Secretion Stress |
| title | Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation |
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