Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia

Ischemic preconditioning (IPC) provides neuroprotection against subsequent severe ischemic insults by specific mechanisms. We tested the hypothesis that IPC attenuates post-ischemic neuronal death in the gerbil hippocampal CA1 region (CA1) throughout hypoxia inducible factor-1α (HIF-1α) and its asso...

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Veröffentlicht in:	Molecular neurobiology 2017-11, Vol.54 (9), p.6984-6998
Hauptverfasser:	Lee, Jae-Chul, Tae, Hyun-Jin, Kim, In Hye, Cho, Jeong Hwi, Lee, Tae-Kyeong, Park, Joon Ha, Ahn, Ji Hyeon, Choi, Soo Young, Bai, Hui Chen, Shin, Bich-Na, Cho, Geum-Sil, Kim, Dae Won, Kang, Il Jun, Kwon, Young-Guen, Kim, Young-Myeong, Won, Moo-Ho, Bae, Eun Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Methoxyestradiol Animals Biomedical and Life Sciences Biomedicine Brain Brain injury CA1 Region, Hippocampal - pathology Cell Biology Cerebral blood flow Gerbillinae Hippocampus Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Ischemia Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Ischemic Preconditioning Male Neurobiology Neurology Neurons Neurons - metabolism Neuroprotection Neurosciences NF-kappa B - metabolism NF-KappaB Inhibitor alpha - metabolism NF-κB protein Pericytes Preconditioning Pyramidal cells Pyramidal Cells - metabolism Translocation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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