DIAGNOSTIC ACCURACY OF SERUM IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE
ABSTRACT Objective: To determine the diagnostic accuracy of serum IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Recent guidelines recommend that if anti-tTG IgA is elevated more than 10 times then HLADQ2 and DQ8 are performed and...
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| Veröffentlicht in: | Pakistan Armed Forces medical journal 2017-08 (4), p.673 |
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| creator | Lodhi, Munir Akmal Ayub, Ammara Saleem, Muhammad Zeeshan Munir, Tehmina |
| description | ABSTRACT Objective: To determine the diagnostic accuracy of serum IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Recent guidelines recommend that if anti-tTG IgA is elevated more than 10 times then HLADQ2 and DQ8 are performed and if any one of them is positive it is confirmatory of celiac disease. [...]a negative test is likely in a patient with marginal pathology (i.e., Marsh I lesion) and does not essentially rule out milder forms of celiac disease. Ninety five (95) children aged between 2 months to 14 years presenting with persistent diarrhea, abdominal pain, vomiting, abdominal distension, constipation, failure to thrive (FTT), idiopathic short stature, unexplained anaemia or iron deficient anaemia unresponsive to treatment and lassitude/weakness were included in the study after taking written informed consent from parents or legal guardian of the patient. CONCLUSION IgA anti-tissue transglutaminase antibody (>25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively. |
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Recent guidelines recommend that if anti-tTG IgA is elevated more than 10 times then HLADQ2 and DQ8 are performed and if any one of them is positive it is confirmatory of celiac disease. [...]a negative test is likely in a patient with marginal pathology (i.e., Marsh I lesion) and does not essentially rule out milder forms of celiac disease. Ninety five (95) children aged between 2 months to 14 years presenting with persistent diarrhea, abdominal pain, vomiting, abdominal distension, constipation, failure to thrive (FTT), idiopathic short stature, unexplained anaemia or iron deficient anaemia unresponsive to treatment and lassitude/weakness were included in the study after taking written informed consent from parents or legal guardian of the patient. CONCLUSION IgA anti-tissue transglutaminase antibody (>25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Abdomen ; Accuracy ; Anemia ; Celiac disease ; Diagnosis ; Endoscopy ; Histochemistry ; Histopathology ; Immunoglobulin A ; Immunoglobulins ; Medical research ; Patients ; Pediatrics ; Small intestine ; Surveys</subject><ispartof>Pakistan Armed Forces medical journal, 2017-08 (4), p.673</ispartof><rights>COPYRIGHT 2017 Knowledge Bylanes</rights><rights>Copyright AsiaNet Pakistan (Pvt) Ltd. Aug 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Lodhi, Munir Akmal</creatorcontrib><creatorcontrib>Ayub, Ammara</creatorcontrib><creatorcontrib>Saleem, Muhammad Zeeshan</creatorcontrib><creatorcontrib>Munir, Tehmina</creatorcontrib><title>DIAGNOSTIC ACCURACY OF SERUM IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE</title><title>Pakistan Armed Forces medical journal</title><description>ABSTRACT Objective: To determine the diagnostic accuracy of serum IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Recent guidelines recommend that if anti-tTG IgA is elevated more than 10 times then HLADQ2 and DQ8 are performed and if any one of them is positive it is confirmatory of celiac disease. [...]a negative test is likely in a patient with marginal pathology (i.e., Marsh I lesion) and does not essentially rule out milder forms of celiac disease. Ninety five (95) children aged between 2 months to 14 years presenting with persistent diarrhea, abdominal pain, vomiting, abdominal distension, constipation, failure to thrive (FTT), idiopathic short stature, unexplained anaemia or iron deficient anaemia unresponsive to treatment and lassitude/weakness were included in the study after taking written informed consent from parents or legal guardian of the patient. CONCLUSION IgA anti-tissue transglutaminase antibody (>25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively.</description><subject>Abdomen</subject><subject>Accuracy</subject><subject>Anemia</subject><subject>Celiac disease</subject><subject>Diagnosis</subject><subject>Endoscopy</subject><subject>Histochemistry</subject><subject>Histopathology</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulins</subject><subject>Medical research</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Small intestine</subject><subject>Surveys</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptjV1rwjAUhsPYYOL8D4FddyRN-pHLLMYaqC2Y9MKrYttEKmo3q_9_cRO2i51zceA9z3nOA5iEFOMgTWn4CCYIERSwmKbPYDaOe-QrIiFF0QT0c8WzotRGCciFqNZcbGC5gFquqxVUGYe8MCowSutKQrPmhc7yyvCVKriW38v3cr6BqoBmKeHdpvTNIWSuuPCZlp59AU9uexjt7D6nwCykEcsgLzMleB7sWMSCBiXWOUstojhEJMGN7WjXpZgR3ESJIwilnUfijrYOUxJjR9omZojZKEy6mEzB64_24zx8Xu14qffD9XzyH2vMKPUQZuyX2m0Ptu5Pbrict-2xH9uaRygOU0xZ5Km3fyjfnT327XCyrvf5n4MvzOFmGg</recordid><startdate>20170831</startdate><enddate>20170831</enddate><creator>Lodhi, Munir Akmal</creator><creator>Ayub, Ammara</creator><creator>Saleem, Muhammad Zeeshan</creator><creator>Munir, Tehmina</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170831</creationdate><title>DIAGNOSTIC ACCURACY OF SERUM IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE</title><author>Lodhi, Munir Akmal ; Ayub, Ammara ; Saleem, Muhammad Zeeshan ; Munir, Tehmina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g959-b07effe4e04120371bed4dd81931b57f3008d7ef6d4cf14361f3cb6909e527d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdomen</topic><topic>Accuracy</topic><topic>Anemia</topic><topic>Celiac disease</topic><topic>Diagnosis</topic><topic>Endoscopy</topic><topic>Histochemistry</topic><topic>Histopathology</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulins</topic><topic>Medical research</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Small intestine</topic><topic>Surveys</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lodhi, Munir Akmal</creatorcontrib><creatorcontrib>Ayub, Ammara</creatorcontrib><creatorcontrib>Saleem, Muhammad Zeeshan</creatorcontrib><creatorcontrib>Munir, Tehmina</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lodhi, Munir Akmal</au><au>Ayub, Ammara</au><au>Saleem, Muhammad Zeeshan</au><au>Munir, Tehmina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DIAGNOSTIC ACCURACY OF SERUM IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2017-08-31</date><risdate>2017</risdate><issue>4</issue><spage>673</spage><pages>673-</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>ABSTRACT Objective: To determine the diagnostic accuracy of serum IgA anti-tissue transglutaminase antibody in the diagnosis of celiac disease taking histopathology as gold standard. Recent guidelines recommend that if anti-tTG IgA is elevated more than 10 times then HLADQ2 and DQ8 are performed and if any one of them is positive it is confirmatory of celiac disease. [...]a negative test is likely in a patient with marginal pathology (i.e., Marsh I lesion) and does not essentially rule out milder forms of celiac disease. Ninety five (95) children aged between 2 months to 14 years presenting with persistent diarrhea, abdominal pain, vomiting, abdominal distension, constipation, failure to thrive (FTT), idiopathic short stature, unexplained anaemia or iron deficient anaemia unresponsive to treatment and lassitude/weakness were included in the study after taking written informed consent from parents or legal guardian of the patient. CONCLUSION IgA anti-tissue transglutaminase antibody (>25 U/ml) was found to be 91.18% sensitive, 29.63% specific and 73.68% accurate in the diagnosis of celiac disease taking histopathology as gold standard with positive and negative predictive values of 76.54% and 57.14% respectively.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Accuracy Anemia Celiac disease Diagnosis Endoscopy Histochemistry Histopathology Immunoglobulin A Immunoglobulins Medical research Patients Pediatrics Small intestine Surveys |
| title | DIAGNOSTIC ACCURACY OF SERUM IGA ANTI-TISSUE TRANSGLUTAMINASE ANTIBODY IN THE DIAGNOSIS OF CELIAC DISEASE |
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