Enhanced expression of tumour suppressor RAR-β by DSPC nano-formulated lipo-ATRA in the lung of B16F10 cell-implanted C57BL6 mice and in A549 cells

All Trans Retinoic acid (ATRA) is an efficient drug for leukemia, but is not efficient therapy for solid cancers. Hence we have used 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol lipo-ATRA to investigate its molecular therapeutic effect on lung cancer. The objective was to find w...

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Veröffentlicht in:	Life sciences (1973) 2017-09, Vol.184, p.10-17
Hauptverfasser:	Berlin Grace, V.M., Reji, Reshma Mahima, Sundaram, Viswanathan
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 A549 Cells Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology B16F10 Cancer Cholesterol DSPC lipo-ATRA Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Immunocytochemistry Immunohistochemistry Leukemia Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Metastasis Mice Mice, Inbred C57BL Phosphatidylcholines - chemistry Phosphocholine Polymerase chain reaction Protein expression RAR-β Receptors, Retinoic Acid - genetics Retinoic acid Retinoic acid receptors Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tretinoin Tretinoin - administration & dosage Tretinoin - pharmacology Tumors
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