Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer
Background Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radi...
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| Veröffentlicht in: | Pediatric blood & cancer 2017-11, Vol.64 (11), p.n/a |
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| description | Background
Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients.
Methods
All consecutive patients ≤18 years treated for DTC in the period 1980–2015 were retrospectively analyzed for early and late side effects of radioiodine. Early side effects include nausea/emesis, radiation thyroiditis, sialadenitis, dry mouth, and transient bone marrow (BM) suppression. Late complications include permanent salivary gland dysfunction, permanent BM suppression, pulmonary fibrosis, second cancers, and fertility problems.
Results
One hundred five pediatric patients were treated with I131 for DTC in our department for a total amount of 302 radioiodine treatments. In total, 127 early complications were recorded: 44 episodes of nausea/emesis; 30 sialoadenitis, 24 thyroiditis, 18 dry mouth, and 11 transient BM suppression. Early side effects were correlated with the amount of radioactivity administered in any treatment. Twelve children developed ≥1 late complication for a total of 20 complications: two permanent salivary gland dysfunction, four permanent BM suppression, five pulmonary fibrosis, four second malignancies, and five fertility alterations. Late events, except fertility alterations, were correlated with the number of therapies and cumulative activities of I131.
Conclusions
In conclusion, early side effects of I131 are associated with the amount of administrated activities of each treatment, while the late effects are correlated with the number of treatments and cumulative activities of radioiodine, except for fertility problems. |
| doi_str_mv | 10.1002/pbc.26595 |
| format | Article |
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Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients.
Methods
All consecutive patients ≤18 years treated for DTC in the period 1980–2015 were retrospectively analyzed for early and late side effects of radioiodine. Early side effects include nausea/emesis, radiation thyroiditis, sialadenitis, dry mouth, and transient bone marrow (BM) suppression. Late complications include permanent salivary gland dysfunction, permanent BM suppression, pulmonary fibrosis, second cancers, and fertility problems.
Results
One hundred five pediatric patients were treated with I131 for DTC in our department for a total amount of 302 radioiodine treatments. In total, 127 early complications were recorded: 44 episodes of nausea/emesis; 30 sialoadenitis, 24 thyroiditis, 18 dry mouth, and 11 transient BM suppression. Early side effects were correlated with the amount of radioactivity administered in any treatment. Twelve children developed ≥1 late complication for a total of 20 complications: two permanent salivary gland dysfunction, four permanent BM suppression, five pulmonary fibrosis, four second malignancies, and five fertility alterations. Late events, except fertility alterations, were correlated with the number of therapies and cumulative activities of I131.
Conclusions
In conclusion, early side effects of I131 are associated with the amount of administrated activities of each treatment, while the late effects are correlated with the number of treatments and cumulative activities of radioiodine, except for fertility problems.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.26595</identifier><identifier>PMID: 28436606</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma, Follicular - pathology ; Adenocarcinoma, Follicular - radiotherapy ; Adolescent ; adverse events ; Bone marrow ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - radiotherapy ; Cell Differentiation - radiation effects ; Child ; Child, Preschool ; Children ; Complications ; Female ; Fertility ; Fibrosis ; Follow-Up Studies ; Hematology ; Humans ; I131 ; Iodine Radioisotopes - adverse effects ; Lung diseases ; Male ; Nausea ; Neoplasm Staging ; Oncology ; pediatric differentiated thyroid cancer ; Pediatrics ; Prognosis ; Pulmonary fibrosis ; Radiation ; Radiation Injuries - etiology ; Radiation Injuries - pathology ; Radioactivity ; radioiodine ; Retrospective Studies ; Salivary gland ; Sialoadenitis ; Side effects ; Thyroid cancer ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - radiotherapy ; Thyroiditis ; Vomiting</subject><ispartof>Pediatric blood & cancer, 2017-11, Vol.64 (11), p.n/a</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-865213b446ee56d316d6f98b4c13af45f7a0de7d4aed5806baab36facb1fca513</citedby><cites>FETCH-LOGICAL-c4195-865213b446ee56d316d6f98b4c13af45f7a0de7d4aed5806baab36facb1fca513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.26595$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.26595$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28436606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albano, Domenico</creatorcontrib><creatorcontrib>Bertagna, Francesco</creatorcontrib><creatorcontrib>Panarotto, Maria Beatrice</creatorcontrib><creatorcontrib>Giubbini, Raffaele</creatorcontrib><title>Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer</title><title>Pediatric blood & cancer</title><addtitle>Pediatr Blood Cancer</addtitle><description>Background
Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients.
Methods
All consecutive patients ≤18 years treated for DTC in the period 1980–2015 were retrospectively analyzed for early and late side effects of radioiodine. Early side effects include nausea/emesis, radiation thyroiditis, sialadenitis, dry mouth, and transient bone marrow (BM) suppression. Late complications include permanent salivary gland dysfunction, permanent BM suppression, pulmonary fibrosis, second cancers, and fertility problems.
Results
One hundred five pediatric patients were treated with I131 for DTC in our department for a total amount of 302 radioiodine treatments. In total, 127 early complications were recorded: 44 episodes of nausea/emesis; 30 sialoadenitis, 24 thyroiditis, 18 dry mouth, and 11 transient BM suppression. Early side effects were correlated with the amount of radioactivity administered in any treatment. Twelve children developed ≥1 late complication for a total of 20 complications: two permanent salivary gland dysfunction, four permanent BM suppression, five pulmonary fibrosis, four second malignancies, and five fertility alterations. Late events, except fertility alterations, were correlated with the number of therapies and cumulative activities of I131.
Conclusions
In conclusion, early side effects of I131 are associated with the amount of administrated activities of each treatment, while the late effects are correlated with the number of treatments and cumulative activities of radioiodine, except for fertility problems.</description><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Adenocarcinoma, Follicular - radiotherapy</subject><subject>Adolescent</subject><subject>adverse events</subject><subject>Bone marrow</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - radiotherapy</subject><subject>Cell Differentiation - radiation effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complications</subject><subject>Female</subject><subject>Fertility</subject><subject>Fibrosis</subject><subject>Follow-Up Studies</subject><subject>Hematology</subject><subject>Humans</subject><subject>I131</subject><subject>Iodine Radioisotopes - adverse effects</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Nausea</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>pediatric differentiated thyroid cancer</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Pulmonary fibrosis</subject><subject>Radiation</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - pathology</subject><subject>Radioactivity</subject><subject>radioiodine</subject><subject>Retrospective Studies</subject><subject>Salivary gland</subject><subject>Sialoadenitis</subject><subject>Side effects</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - radiotherapy</subject><subject>Thyroiditis</subject><subject>Vomiting</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQQC0EoqUw8AeQJSaGtHZiu8kIVfmQKsEAA5Pl2GfhKo2LnYLy7zGksDHdnfT0TnoInVMypYTks22tp7ngFT9AY8oZzzih88O_nVQjdBLjOqGC8PIYjfKSFUIQMUavSxWaHqvW4EZ1gJX5gBABg7Wgu4i9xUEZ5503rgVsfcBbME51wWlsXKICtF26weDurQ_eGaxVqyGcoiOrmghn-zlBL7fL58V9tnq8e1hcrzLNaMWzUvCcFjVjAoALU1BhhK3KmmlaKMu4nStiYG6YAsNLImql6kJYpWtqteK0mKDLwbsN_n0HsZNrvwtteilpxXIhKiaqRF0NlA4-xgBWboPbqNBLSuR3RJkiyp-Iib3YG3f1Bswf-VstAbMB-HQN9P-b5NPNYlB-AYcpfE8</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Albano, Domenico</creator><creator>Bertagna, Francesco</creator><creator>Panarotto, Maria Beatrice</creator><creator>Giubbini, Raffaele</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201711</creationdate><title>Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer</title><author>Albano, Domenico ; Bertagna, Francesco ; Panarotto, Maria Beatrice ; Giubbini, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-865213b446ee56d316d6f98b4c13af45f7a0de7d4aed5806baab36facb1fca513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Adenocarcinoma, Follicular - radiotherapy</topic><topic>Adolescent</topic><topic>adverse events</topic><topic>Bone marrow</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - radiotherapy</topic><topic>Cell Differentiation - radiation effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complications</topic><topic>Female</topic><topic>Fertility</topic><topic>Fibrosis</topic><topic>Follow-Up Studies</topic><topic>Hematology</topic><topic>Humans</topic><topic>I131</topic><topic>Iodine Radioisotopes - adverse effects</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Nausea</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>pediatric differentiated thyroid cancer</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Pulmonary fibrosis</topic><topic>Radiation</topic><topic>Radiation Injuries - etiology</topic><topic>Radiation Injuries - pathology</topic><topic>Radioactivity</topic><topic>radioiodine</topic><topic>Retrospective Studies</topic><topic>Salivary gland</topic><topic>Sialoadenitis</topic><topic>Side effects</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Thyroiditis</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albano, Domenico</creatorcontrib><creatorcontrib>Bertagna, Francesco</creatorcontrib><creatorcontrib>Panarotto, Maria Beatrice</creatorcontrib><creatorcontrib>Giubbini, Raffaele</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albano, Domenico</au><au>Bertagna, Francesco</au><au>Panarotto, Maria Beatrice</au><au>Giubbini, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr Blood Cancer</addtitle><date>2017-11</date><risdate>2017</risdate><volume>64</volume><issue>11</issue><epage>n/a</epage><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
Radioiodine‐131 (I131) therapy for differentiated thyroid cancer (DTC) is generally a safe and effective treatment, but it has some potential side effects, which have been well described in adults but less analyzed in children. Our aim was to describe early and late adverse events of radioactive I131 in pediatric patients.
Methods
All consecutive patients ≤18 years treated for DTC in the period 1980–2015 were retrospectively analyzed for early and late side effects of radioiodine. Early side effects include nausea/emesis, radiation thyroiditis, sialadenitis, dry mouth, and transient bone marrow (BM) suppression. Late complications include permanent salivary gland dysfunction, permanent BM suppression, pulmonary fibrosis, second cancers, and fertility problems.
Results
One hundred five pediatric patients were treated with I131 for DTC in our department for a total amount of 302 radioiodine treatments. In total, 127 early complications were recorded: 44 episodes of nausea/emesis; 30 sialoadenitis, 24 thyroiditis, 18 dry mouth, and 11 transient BM suppression. Early side effects were correlated with the amount of radioactivity administered in any treatment. Twelve children developed ≥1 late complication for a total of 20 complications: two permanent salivary gland dysfunction, four permanent BM suppression, five pulmonary fibrosis, four second malignancies, and five fertility alterations. Late events, except fertility alterations, were correlated with the number of therapies and cumulative activities of I131.
Conclusions
In conclusion, early side effects of I131 are associated with the amount of administrated activities of each treatment, while the late effects are correlated with the number of treatments and cumulative activities of radioiodine, except for fertility problems.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28436606</pmid><doi>10.1002/pbc.26595</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma, Follicular - pathology Adenocarcinoma, Follicular - radiotherapy Adolescent adverse events Bone marrow Carcinoma, Papillary - pathology Carcinoma, Papillary - radiotherapy Cell Differentiation - radiation effects Child Child, Preschool Children Complications Female Fertility Fibrosis Follow-Up Studies Hematology Humans I131 Iodine Radioisotopes - adverse effects Lung diseases Male Nausea Neoplasm Staging Oncology pediatric differentiated thyroid cancer Pediatrics Prognosis Pulmonary fibrosis Radiation Radiation Injuries - etiology Radiation Injuries - pathology Radioactivity radioiodine Retrospective Studies Salivary gland Sialoadenitis Side effects Thyroid cancer Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy Thyroiditis Vomiting |
| title | Early and late adverse effects of radioiodine for pediatric differentiated thyroid cancer |
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