MHY451 induces cell cycle arrest and apoptosis by ROS generation in HCT116 human colorectal cancer cells

Colorectal cancer (CRC) is the third most frequently diagnosed cancer and cause of cancer-related deaths. Despite advancements in conventional therapeutic approaches to CRC, most patients with CRC die of their disease. There is a need to develop novel therapeutic agents for this malignancy. Therefor...

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Veröffentlicht in:	Oncology reports 2017-09, Vol.38 (3), p.1783-1789
Hauptverfasser:	Hwang, Na Lam, Kang, Yong Jung, Sung, Bokyung, Hwang, Seong Yeon, Jang, Jung Yoon, Oh, Hye Jin, Ahn, Yu Ra, Kim, Do Hyun, Kim, Su Jeong, Ullah, Sultan, Hossain, Mohammad Akbar, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - metabolism Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Cancer therapies Care and treatment Caspases - metabolism Cell cycle Cell Cycle Checkpoints - drug effects Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy colon cancer cells Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Cyclin B1 - metabolism Cyclin-dependent kinases Cytochrome Development and progression G2 Phase Cell Cycle Checkpoints - drug effects Gene expression Genetic aspects HCT116 Cells Health aspects Humans Kinases MHY451 Oncogenes Poly(ADP-ribose) Polymerases - metabolism Proteins Reactive oxygen species Reactive Oxygen Species - metabolism
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