Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median o...
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| Veröffentlicht in: | Frontiers of medicine 2009-09, Vol.3 (3), p.271-276 |
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| creator | Liu, Lili Wang, Jiyao She, Weimin |
| description | The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline (
P
= 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis (
P
= 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up. |
| doi_str_mv | 10.1007/s11684-009-0054-1 |
| format | Article |
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P
= 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis (
P
= 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.</description><identifier>ISSN: 1673-7342</identifier><identifier>ISSN: 2095-0217</identifier><identifier>EISSN: 1673-7458</identifier><identifier>EISSN: 2095-0225</identifier><identifier>DOI: 10.1007/s11684-009-0054-1</identifier><language>eng</language><publisher>Heidelberg: SP Higher Education Press</publisher><subject>Deoxyribonucleic acid ; DNA ; Hepatitis ; Hepatitis B ; Interferon ; Liver ; Liver cirrhosis ; Medicine ; Medicine & Public Health ; Research Article</subject><ispartof>Frontiers of medicine, 2009-09, Vol.3 (3), p.271-276</ispartof><rights>Higher Education Press and Springer-Verlag GmbH 2009</rights><rights>Frontiers of Medicine in China is a copyright of Springer, 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2311-1499b3b9fc9dedad64015f43a28d672ed97a4b508c58fb390917ae706de4f13d3</citedby><cites>FETCH-LOGICAL-c2311-1499b3b9fc9dedad64015f43a28d672ed97a4b508c58fb390917ae706de4f13d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Liu, Lili</creatorcontrib><creatorcontrib>Wang, Jiyao</creatorcontrib><creatorcontrib>She, Weimin</creatorcontrib><title>Correlation between viral load and liver cirrhosis in chronic hepatitis B patients</title><title>Frontiers of medicine</title><addtitle>Front. Med. China</addtitle><description>The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline (
P
= 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis (
P
= 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.</description><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Interferon</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Research Article</subject><issn>1673-7342</issn><issn>2095-0217</issn><issn>1673-7458</issn><issn>2095-0225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE9LxDAQxYMouK5-AG8Bz9VMkzbNURf_wYIgeg5pM7VZarIm3RW_vS1V8OJhmMfw3hv4EXIO7BIYk1cJoKxExpgapxAZHJAFlJJnUhTV4a_mIj8mJyltGCuZ4GJBnlchRuzN4IKnNQ6fiJ7uXTQ97YOx1HhLe7fHSBsXYxeSS9R52nQxeNfQDrdjdBiPN3RS6Id0So5a0yc8-9lL8np3-7J6yNZP94-r63XW5BwgA6FUzWvVNsqiNbYUDIpWcJNXtpQ5WiWNqAtWNUXV1lwxBdKgZKVF0QK3fEku5t5tDB87TIPehF3040sNSkAhC5AwumB2NTGkFLHV2-jeTfzSwPSETs_o9IhOT-j0lMnnTBq9_g3jn-Z_Q98kAHEy</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Liu, Lili</creator><creator>Wang, Jiyao</creator><creator>She, Weimin</creator><general>SP Higher Education Press</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20090901</creationdate><title>Correlation between viral load and liver cirrhosis in chronic hepatitis B patients</title><author>Liu, Lili ; Wang, Jiyao ; She, Weimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2311-1499b3b9fc9dedad64015f43a28d672ed97a4b508c58fb390917ae706de4f13d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Interferon</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lili</creatorcontrib><creatorcontrib>Wang, Jiyao</creatorcontrib><creatorcontrib>She, Weimin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Frontiers of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lili</au><au>Wang, Jiyao</au><au>She, Weimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between viral load and liver cirrhosis in chronic hepatitis B patients</atitle><jtitle>Frontiers of medicine</jtitle><stitle>Front. Med. China</stitle><date>2009-09-01</date><risdate>2009</risdate><volume>3</volume><issue>3</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>1673-7342</issn><issn>2095-0217</issn><eissn>1673-7458</eissn><eissn>2095-0225</eissn><abstract>The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline (
P
= 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis (
P
= 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.</abstract><cop>Heidelberg</cop><pub>SP Higher Education Press</pub><doi>10.1007/s11684-009-0054-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Deoxyribonucleic acid DNA Hepatitis Hepatitis B Interferon Liver Liver cirrhosis Medicine Medicine & Public Health Research Article |
| title | Correlation between viral load and liver cirrhosis in chronic hepatitis B patients |
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