TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy
ABSTRACT Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6‐carbobenzyloxy‐l‐lysine)‐block‐poly(2‐methacryloyloxyethyl phosphorylcholine) (TPE‐P...
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| Veröffentlicht in: | Journal of applied polymer science 2018-01, Vol.135 (1), p.n/a |
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| creator | Zhuang, Weihua Ma, Boxuan Liu, Gongyan Li, Gaocan Wang, Yunbing |
| description | ABSTRACT
Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6‐carbobenzyloxy‐l‐lysine)‐block‐poly(2‐methacryloyloxyethyl phosphorylcholine) (TPE‐PLys‐b‐PMPC) copolymer are successfully prepared. Such biomimetic and biodegradable TPE‐PLys‐b‐PMPC micelles exhibit remarkable aggregation‐induced emission (AIE) feature and great biocompatibility, showing great potential for bioimaging application. In addition, anticancer drug doxorubicin (DOX) can be incorporated into the core of micelles and the intracellular release of DOX can be furthermore traced through the fluorescent imaging of these AIE micelles. As expected, this DOX‐loading polymeric micelle shows significant growth inhibition against HeLa cells and 4T1 cells and such TPE‐PLys‐b‐PMPC micelles would be a promising drug carrier for potential cancer therapy and bioimaging. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45651. |
| doi_str_mv | 10.1002/app.45651 |
| format | Article |
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Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6‐carbobenzyloxy‐l‐lysine)‐block‐poly(2‐methacryloyloxyethyl phosphorylcholine) (TPE‐PLys‐b‐PMPC) copolymer are successfully prepared. Such biomimetic and biodegradable TPE‐PLys‐b‐PMPC micelles exhibit remarkable aggregation‐induced emission (AIE) feature and great biocompatibility, showing great potential for bioimaging application. In addition, anticancer drug doxorubicin (DOX) can be incorporated into the core of micelles and the intracellular release of DOX can be furthermore traced through the fluorescent imaging of these AIE micelles. As expected, this DOX‐loading polymeric micelle shows significant growth inhibition against HeLa cells and 4T1 cells and such TPE‐PLys‐b‐PMPC micelles would be a promising drug carrier for potential cancer therapy and bioimaging. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45651.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.45651</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Biocompatibility ; Biodegradability ; biodegradable ; biomedical applications ; biomimetic ; Biomimetics ; Block copolymers ; Cancer ; Cancer therapies ; Doxorubicin ; Drug carriers ; Drug delivery systems ; Fluorescence ; Lysine ; Materials science ; Medical imaging ; Methacryloyloxyethyl phosphorylcholine ; Micelles ; Phosphorylcholine ; Polymers ; Therapy</subject><ispartof>Journal of applied polymer science, 2018-01, Vol.135 (1), p.n/a</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4021-5614e789963024dc0bcefa58b9f1aa79a0746b569d5550c8dcf58334af40cd933</citedby><cites>FETCH-LOGICAL-c4021-5614e789963024dc0bcefa58b9f1aa79a0746b569d5550c8dcf58334af40cd933</cites><orcidid>0000-0003-0492-7527</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.45651$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.45651$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Zhuang, Weihua</creatorcontrib><creatorcontrib>Ma, Boxuan</creatorcontrib><creatorcontrib>Liu, Gongyan</creatorcontrib><creatorcontrib>Li, Gaocan</creatorcontrib><creatorcontrib>Wang, Yunbing</creatorcontrib><title>TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy</title><title>Journal of applied polymer science</title><description>ABSTRACT
Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6‐carbobenzyloxy‐l‐lysine)‐block‐poly(2‐methacryloyloxyethyl phosphorylcholine) (TPE‐PLys‐b‐PMPC) copolymer are successfully prepared. Such biomimetic and biodegradable TPE‐PLys‐b‐PMPC micelles exhibit remarkable aggregation‐induced emission (AIE) feature and great biocompatibility, showing great potential for bioimaging application. In addition, anticancer drug doxorubicin (DOX) can be incorporated into the core of micelles and the intracellular release of DOX can be furthermore traced through the fluorescent imaging of these AIE micelles. As expected, this DOX‐loading polymeric micelle shows significant growth inhibition against HeLa cells and 4T1 cells and such TPE‐PLys‐b‐PMPC micelles would be a promising drug carrier for potential cancer therapy and bioimaging. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45651.</description><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>biodegradable</subject><subject>biomedical applications</subject><subject>biomimetic</subject><subject>Biomimetics</subject><subject>Block copolymers</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Doxorubicin</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Fluorescence</subject><subject>Lysine</subject><subject>Materials science</subject><subject>Medical imaging</subject><subject>Methacryloyloxyethyl phosphorylcholine</subject><subject>Micelles</subject><subject>Phosphorylcholine</subject><subject>Polymers</subject><subject>Therapy</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQhS0EEqWw4AaWWLFIayd2Ei8rVKBSJbooa2viTIKr_OGkoO44AmfkJLgNW1ajmffNzNMj5JazGWcsnEPXzYSMJT8jE85UEog4TM_JxGs8SJWSl-Sq73eMcS5ZPCHNdrP8-fo2bbPblzBgTjPb1rbGwRoKzanNsXSQQ1Yh7drqUKPzWm0NVn5StI4uVksKZrAfSI9DamsobVOe9g00Bh0d3tBBd7gmFwVUPd781Sl5fVxuH56D9cvT6mGxDow4GpUxF5h4u3HEQpEblhksQKaZKjhAooAlIs5krHIpJTNpbgqZRpGAQjCTqyiakrvxbufa9z32g961e9f4l5orwcMw5Kny1P1IGdf2vcNCd857dwfNmT7GqX2c-hSnZ-cj-2krPPwP6sVmM278Aq5Id9g</recordid><startdate>20180105</startdate><enddate>20180105</enddate><creator>Zhuang, Weihua</creator><creator>Ma, Boxuan</creator><creator>Liu, Gongyan</creator><creator>Li, Gaocan</creator><creator>Wang, Yunbing</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-0492-7527</orcidid></search><sort><creationdate>20180105</creationdate><title>TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy</title><author>Zhuang, Weihua ; Ma, Boxuan ; Liu, Gongyan ; Li, Gaocan ; Wang, Yunbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4021-5614e789963024dc0bcefa58b9f1aa79a0746b569d5550c8dcf58334af40cd933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>biodegradable</topic><topic>biomedical applications</topic><topic>biomimetic</topic><topic>Biomimetics</topic><topic>Block copolymers</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Doxorubicin</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Fluorescence</topic><topic>Lysine</topic><topic>Materials science</topic><topic>Medical imaging</topic><topic>Methacryloyloxyethyl phosphorylcholine</topic><topic>Micelles</topic><topic>Phosphorylcholine</topic><topic>Polymers</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhuang, Weihua</creatorcontrib><creatorcontrib>Ma, Boxuan</creatorcontrib><creatorcontrib>Liu, Gongyan</creatorcontrib><creatorcontrib>Li, Gaocan</creatorcontrib><creatorcontrib>Wang, Yunbing</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhuang, Weihua</au><au>Ma, Boxuan</au><au>Liu, Gongyan</au><au>Li, Gaocan</au><au>Wang, Yunbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy</atitle><jtitle>Journal of applied polymer science</jtitle><date>2018-01-05</date><risdate>2018</risdate><volume>135</volume><issue>1</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
Smart nanocarrier for simultaneous drug delivery and cellular imaging is ideal for both cancer therapy and diagnosis. In this work, polymeric micelles based on the tetraphenylethene (TPE) conjugated poly(N6‐carbobenzyloxy‐l‐lysine)‐block‐poly(2‐methacryloyloxyethyl phosphorylcholine) (TPE‐PLys‐b‐PMPC) copolymer are successfully prepared. Such biomimetic and biodegradable TPE‐PLys‐b‐PMPC micelles exhibit remarkable aggregation‐induced emission (AIE) feature and great biocompatibility, showing great potential for bioimaging application. In addition, anticancer drug doxorubicin (DOX) can be incorporated into the core of micelles and the intracellular release of DOX can be furthermore traced through the fluorescent imaging of these AIE micelles. As expected, this DOX‐loading polymeric micelle shows significant growth inhibition against HeLa cells and 4T1 cells and such TPE‐PLys‐b‐PMPC micelles would be a promising drug carrier for potential cancer therapy and bioimaging. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45651.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/app.45651</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0492-7527</orcidid></addata></record> |
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| subjects | Biocompatibility Biodegradability biodegradable biomedical applications biomimetic Biomimetics Block copolymers Cancer Cancer therapies Doxorubicin Drug carriers Drug delivery systems Fluorescence Lysine Materials science Medical imaging Methacryloyloxyethyl phosphorylcholine Micelles Phosphorylcholine Polymers Therapy |
| title | TPE‐conjugated biomimetic and biodegradable polymeric micelle for AIE active cell imaging and cancer therapy |
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