A longevity study with enhancer substances (selegiline, BPAP) detected an unknown tumor-manifestation-suppressing regulation in rat brain

First proof to show that (−)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP), the tryptamine-d...

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Veröffentlicht in:	Life sciences (1973) 2017-08, Vol.182, p.57-64
Hauptverfasser:	Knoll, J., Baghy, K., Eckhardt, S., Ferdinandy, P., Garami, M., Harsing, L.G., Hauser, P., Mervai, Z., Pocza, T., Schaff, Z., Schuler, D., Miklya, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	(2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP) Amine oxidase (flavin-containing) Animals Antineoplastic Agents - pharmacology Benzofuran Benzofurans - administration & dosage Benzofurans - pharmacology Biotechnology Brain Brain - drug effects Brain - metabolism Cell Line, Tumor Cisplatin Cognitive enhancement Cytotoxicity Dose-Response Relationship, Drug Enhancer substances Enhancer-sensitive tumor-manifestation-suppressing (TMS) regulation Etoposide Fibromyxosarcoma Fibrosarcoma - prevention & control Humans Longevity Longevity - drug effects Male Markers Medulloblastoma Medulloblastoma - drug therapy Monoamine Oxidase Inhibitors - administration & dosage Monoamine Oxidase Inhibitors - pharmacology Phenethylamine Phenylethylamine Rats Rats, Wistar Regulations Selegiline Selegiline - administration & dosage Selegiline - pharmacology Selegiline/(−)-deprenyl Temozolomide Tryptamine Tumor cells Vesicular monoamine transporter 2 Vincristine
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Zusammenfassung:	First proof to show that (−)-deprenyl/selegiline (DEP), the first selective inhibitor of MAO-B, later identified as the first β-phenylethylamine (PEA)-derived synthetic catecholaminergic activity enhancer (CAE) substance and (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine (BPAP), the tryptamine-derived presently known most potent, selective, synthetic enhancer substance, are specific markers of unknown enhancer-sensitive brain regulations. Longevity study disclosing the operation of tumor-manifestation-suppressing (TMS) regulation in rat brain. Immonohistochemical identification of a fibromyxosarcoma in rats. Experiments with human medulloblastoma cell lines. Analysis of the mechanism of action of enhancer substances. Whereas 20/40 saline-treated rats manifested a fibromyxosarcoma, in groups of rats treated with 0.001mg/kg DEP: 15/40 rats; with 0.1mg/kg DEP: 11/40 rats (P
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2017.06.010