Post-Partum Hemoglobinuria (PPH) in Bovine

Postpartum hemoglobinuria is a non-infectious haemolytic syndrome of adult cattle and buffaloes, a potent thread to these animals in India and Pakistan affecting considerable number of animals every year during advance pregnancy and early lactation. It is characterized by intra venous hemolysis, hemoglobinuria, severe anemia and death due to anemia and anoxia. The exact pathogenesis of this problem is not fully understood. The exhaustive studies have been undertaken and are still in progress to elucidate the exact cause of intravascular hemolysis which is the cause of hemoglobinuria in this disease. However, phosphorus deficiency in high yielding animals during early stage of lactation is widely believed to be associated with postpartum hemoglobinuria. A variety of risk factors have been reported to be associated with this disease in different part of world. Hematology and urinalysis are most commonly adopted diagnostic tools for the PPH. Moreover, Lecithin cholesterol acyltransferase (LCAT) activity may be used a more specific diagnostic indicator of PPH. Various studies have been suggested that administration of sodium acid phosphate along with supportive therapy with anti-oxidants and other important minsrals, can be used as a therapeutic protocol for management of PPH.