Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti‐Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta‐Carotene, and Spirulina fusiformis: Role of NF‐κB, iNOS, IL‐6, and IL‐10
ABSTRACT Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti‐tu...
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| description | ABSTRACT
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti‐tuberculosis drug induced hepatotoxicity. INH and RIF were administered to Wistar albino rats for 28 days to induce hepatotoxicity. S. fusiformis, vitamin B12, and beta‐carotene were co‐administered with INH and RIF and their hepatoprotective, antioxidant, and immunomodulatory roles were studied through blood and liver analysis. Changes induced by INH and RIF in antioxidants, cytokines (IL‐6 and IL‐10) and expression of Nuclear Factor‐κB (NF‐κB) and Nitric Oxide Synthase (iNOS) were also studied. Supplement treatment caused restoration of liver function parameters to normal levels along with reversal of inflammatory changes in IL‐6 and IL‐10 levels. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the pivotal role of NF‐kB and the equivalence in antioxidant efficacy of vitamin B12 and beta‐carotene compared to Spirulina fusiformis. J. Cell. Biochem. 118: 3825–3833, 2017. © 2017 Wiley Periodicals, Inc.
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the importance of vitamin B12 and beta‐carotene in giving S. fusiformis its hepatoprotective function and the pivotal role of NF‐κB. |
| doi_str_mv | 10.1002/jcb.26032 |
| format | Article |
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Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti‐tuberculosis drug induced hepatotoxicity. INH and RIF were administered to Wistar albino rats for 28 days to induce hepatotoxicity. S. fusiformis, vitamin B12, and beta‐carotene were co‐administered with INH and RIF and their hepatoprotective, antioxidant, and immunomodulatory roles were studied through blood and liver analysis. Changes induced by INH and RIF in antioxidants, cytokines (IL‐6 and IL‐10) and expression of Nuclear Factor‐κB (NF‐κB) and Nitric Oxide Synthase (iNOS) were also studied. Supplement treatment caused restoration of liver function parameters to normal levels along with reversal of inflammatory changes in IL‐6 and IL‐10 levels. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the pivotal role of NF‐kB and the equivalence in antioxidant efficacy of vitamin B12 and beta‐carotene compared to Spirulina fusiformis. J. Cell. Biochem. 118: 3825–3833, 2017. © 2017 Wiley Periodicals, Inc.
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the importance of vitamin B12 and beta‐carotene in giving S. fusiformis its hepatoprotective function and the pivotal role of NF‐κB.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.26032</identifier><identifier>PMID: 28387444</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antioxidants ; Antitubercular Agents - adverse effects ; Antitubercular Agents - pharmacology ; beta Carotene - pharmacology ; BETA‐CAROTENE ; Carotene ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - metabolism ; Cyanocobalamin ; Cytokines ; Dietary Supplements ; Female ; HEPATOTOXICITY ; Immunohistochemistry ; Immunomodulation ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Interleukin-10 - metabolism ; Interleukin-6 - metabolism ; ISONIAZID ; Liver ; Liver - metabolism ; Liver - pathology ; NF-kappa B - metabolism ; NF-κB protein ; Nitric oxide ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; Oxidative stress ; Oxidative Stress - drug effects ; Proliferating cell nuclear antigen ; Rats ; Rats, Wistar ; Restoration ; RIFAMPICIN ; Rifampin ; Rodents ; Spirulina ; SPIRULINA FUSIFORMIS ; Tissues ; Tuberculosis ; Vitamin A ; Vitamin B 12 - pharmacology ; VITAMIN B12</subject><ispartof>Journal of cellular biochemistry, 2017-11, Vol.118 (11), p.3825-3833</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-96826547219d86ad4f2d0184b56d9ecf8ae6528c8263f583704415fae3f9d4d83</citedby><cites>FETCH-LOGICAL-c3532-96826547219d86ad4f2d0184b56d9ecf8ae6528c8263f583704415fae3f9d4d83</cites><orcidid>0000-0003-2073-5971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.26032$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.26032$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28387444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joseph Martin, Sherry</creatorcontrib><creatorcontrib>Evan Prince, Sabina</creatorcontrib><title>Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti‐Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta‐Carotene, and Spirulina fusiformis: Role of NF‐κB, iNOS, IL‐6, and IL‐10</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>ABSTRACT
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti‐tuberculosis drug induced hepatotoxicity. INH and RIF were administered to Wistar albino rats for 28 days to induce hepatotoxicity. S. fusiformis, vitamin B12, and beta‐carotene were co‐administered with INH and RIF and their hepatoprotective, antioxidant, and immunomodulatory roles were studied through blood and liver analysis. Changes induced by INH and RIF in antioxidants, cytokines (IL‐6 and IL‐10) and expression of Nuclear Factor‐κB (NF‐κB) and Nitric Oxide Synthase (iNOS) were also studied. Supplement treatment caused restoration of liver function parameters to normal levels along with reversal of inflammatory changes in IL‐6 and IL‐10 levels. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the pivotal role of NF‐kB and the equivalence in antioxidant efficacy of vitamin B12 and beta‐carotene compared to Spirulina fusiformis. J. Cell. Biochem. 118: 3825–3833, 2017. © 2017 Wiley Periodicals, Inc.
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the importance of vitamin B12 and beta‐carotene in giving S. fusiformis its hepatoprotective function and the pivotal role of NF‐κB.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antitubercular Agents - adverse effects</subject><subject>Antitubercular Agents - pharmacology</subject><subject>beta Carotene - pharmacology</subject><subject>BETA‐CAROTENE</subject><subject>Carotene</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Cyanocobalamin</subject><subject>Cytokines</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>HEPATOTOXICITY</subject><subject>Immunohistochemistry</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>ISONIAZID</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Proliferating cell nuclear antigen</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restoration</subject><subject>RIFAMPICIN</subject><subject>Rifampin</subject><subject>Rodents</subject><subject>Spirulina</subject><subject>SPIRULINA FUSIFORMIS</subject><subject>Tissues</subject><subject>Tuberculosis</subject><subject>Vitamin A</subject><subject>Vitamin B 12 - pharmacology</subject><subject>VITAMIN B12</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EokNhwQsgS6yQJq3_knHYdQKFotCROgMsIye-AY-SeLCdwux4BJ6Hh2DNmifB0xR2rO65V985d3EQekzJCSWEnW6b-oRlhLM7aEZJvkhEJsRdNCMLThLGKTtCD7zfEkLynLP76IhJLhdCiBn6Vdh-p5wK5hrwW6vHLko7YNviEq6h8we1-mr0RKyDA--xGXD4BLiMJ3cAzoZgfn_7vhlrcM3YWW88fuHGj3jjQAXQ-IPxQTl8pYLH9R6_N0H1MWRJ2RwvIahoLpSzAQaYYzVovN4ZN3ZmULgdvWmt641_jq9sB4d_l-fR8PPHco7N5Wo9xxdl3LPJeaMpeYjutarz8Oh2HqN35y83xeukXL26KM7KpOEpZ0meSZalYsFormWmtGiZJlSKOs10Dk0rFWQpk02keJtKviBC0LRVwNtcCy35MXo65e6c_TyCD9XWjm6ILyua81wSSUkWqWcT1TjrvYO22jnTK7evKKkOHVaxw-qmw8g-uU0c6x70P_JvaRE4nYAvpoP9_5OqN8VyivwDKuep9w</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Joseph Martin, Sherry</creator><creator>Evan Prince, Sabina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-2073-5971</orcidid></search><sort><creationdate>201711</creationdate><title>Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti‐Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta‐Carotene, and Spirulina fusiformis: Role of NF‐κB, iNOS, IL‐6, and IL‐10</title><author>Joseph Martin, Sherry ; Evan Prince, Sabina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-96826547219d86ad4f2d0184b56d9ecf8ae6528c8263f583704415fae3f9d4d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antitubercular Agents - adverse effects</topic><topic>Antitubercular Agents - pharmacology</topic><topic>beta Carotene - pharmacology</topic><topic>BETA‐CAROTENE</topic><topic>Carotene</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Cyanocobalamin</topic><topic>Cytokines</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>HEPATOTOXICITY</topic><topic>Immunohistochemistry</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>ISONIAZID</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Nitric-oxide synthase</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Proliferating cell nuclear antigen</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Restoration</topic><topic>RIFAMPICIN</topic><topic>Rifampin</topic><topic>Rodents</topic><topic>Spirulina</topic><topic>SPIRULINA FUSIFORMIS</topic><topic>Tissues</topic><topic>Tuberculosis</topic><topic>Vitamin A</topic><topic>Vitamin B 12 - pharmacology</topic><topic>VITAMIN B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joseph Martin, Sherry</creatorcontrib><creatorcontrib>Evan Prince, Sabina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joseph Martin, Sherry</au><au>Evan Prince, Sabina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti‐Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta‐Carotene, and Spirulina fusiformis: Role of NF‐κB, iNOS, IL‐6, and IL‐10</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2017-11</date><risdate>2017</risdate><volume>118</volume><issue>11</issue><spage>3825</spage><epage>3833</epage><pages>3825-3833</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>ABSTRACT
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. We also tried to elucidate the inflammatory mechanism behind anti‐tuberculosis drug induced hepatotoxicity. INH and RIF were administered to Wistar albino rats for 28 days to induce hepatotoxicity. S. fusiformis, vitamin B12, and beta‐carotene were co‐administered with INH and RIF and their hepatoprotective, antioxidant, and immunomodulatory roles were studied through blood and liver analysis. Changes induced by INH and RIF in antioxidants, cytokines (IL‐6 and IL‐10) and expression of Nuclear Factor‐κB (NF‐κB) and Nitric Oxide Synthase (iNOS) were also studied. Supplement treatment caused restoration of liver function parameters to normal levels along with reversal of inflammatory changes in IL‐6 and IL‐10 levels. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the pivotal role of NF‐kB and the equivalence in antioxidant efficacy of vitamin B12 and beta‐carotene compared to Spirulina fusiformis. J. Cell. Biochem. 118: 3825–3833, 2017. © 2017 Wiley Periodicals, Inc.
Isoniazid (INH) and Rifampicin (RIF) are known hepatotoxic agents. We compared the efficacy of Spirulina fusiformis and its active components vitamin B12 and beta‐carotene in attenuating INH and RIF induced hepatotoxicity. Liver PCNA, iNOS, and NF‐κB expression were reduced in the supplement treated tissues compared to INH and RIF treated rats as evidenced by immunohistochemistry and quantitative PCR. Correlation of IL‐6 levels, PCNA, and iNOS with NF‐κB showed its pivotal role in the inflammatory process. Study shows the importance of vitamin B12 and beta‐carotene in giving S. fusiformis its hepatoprotective function and the pivotal role of NF‐κB.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28387444</pmid><doi>10.1002/jcb.26032</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2073-5971</orcidid></addata></record> |
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| ispartof | Journal of cellular biochemistry, 2017-11, Vol.118 (11), p.3825-3833 |
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| language | eng |
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| subjects | Animals Antioxidants Antitubercular Agents - adverse effects Antitubercular Agents - pharmacology beta Carotene - pharmacology BETA‐CAROTENE Carotene Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Cyanocobalamin Cytokines Dietary Supplements Female HEPATOTOXICITY Immunohistochemistry Immunomodulation Inflammation Interleukin 10 Interleukin 6 Interleukin-10 - metabolism Interleukin-6 - metabolism ISONIAZID Liver Liver - metabolism Liver - pathology NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxidative stress Oxidative Stress - drug effects Proliferating cell nuclear antigen Rats Rats, Wistar Restoration RIFAMPICIN Rifampin Rodents Spirulina SPIRULINA FUSIFORMIS Tissues Tuberculosis Vitamin A Vitamin B 12 - pharmacology VITAMIN B12 |
| title | Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti‐Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta‐Carotene, and Spirulina fusiformis: Role of NF‐κB, iNOS, IL‐6, and IL‐10 |
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