Ruthenium‐Catalyzed Oxidative Formal Aza‐Diels–Alder Reaction: Enantioselective Synthesis of Benzo[a]quinolizine‐2‐ones

A method for the preparation of thermodynamic (4R,11bS)‐benzo[a]quinolizine‐2‐one derivatives in good enantio‐ and diastereoselectivity by a one‐pot oxidative formal aza‐Diels–Alder reaction of 1,2,3,4‐tetrahydroisoquinolines and α,β‐unsaturated ketones is described. The reaction proceeds via tandem...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Advanced synthesis & catalysis 2017-09, Vol.359 (18), p.3095-3101
Hauptverfasser:	Yao, Yuan, Zhu, Hai‐Jie, Li, Fang, Zhu, Cheng‐Feng, Luo, Yun‐Fei, Wu, Xiang, Kantchev, Eric Assen B.
Format:	Artikel
Sprache:	eng
Schlagworte:	amine oxidation aza-Diels–Alder reaction benzo[a]quinolizine-2-ones Butyl hydroperoxide Chemical synthesis Cycloaddition Dehydrogenation Diels-Alder reactions enantioselective catalysis Ketones Ruthenium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!