Synthesis, Characterization, and Anti‐inflammatory Activity of Novel Isoxazolyl‐4‐(2‐oxo‐2,3‐dihydro‐1H‐3‐indolyl)pyrrole‐3‐carboxylates

Synthesis, Characterization, and Anti‐inflammatory Activity of Novel Isoxazolyl‐4‐(2‐oxo‐2,3‐dihydro‐1H‐3‐indolyl)pyrrole‐3‐carboxylates

A series of novel isoxazolyl‐4‐(2‐oxo‐2,3‐dihydro‐1H‐3‐indolyl)pyrrole‐3‐carboxylates (17a–i) were synthesized by a three‐component reaction of 4‐amino‐3‐methyl‐5‐styrylisoxazole 14, β‐keto ester 15, and 3‐phenacylideneoxindole 16, in the presence of CAN catalyst in ethanol. The structures of the sy...

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Veröffentlicht in:Journal of heterocyclic chemistry 2017-09, Vol.54 (5), p.2830-2837
Hauptverfasser: Saini, Ramakrishna, Dharavath, Nagaraju, Eligeti, Rajanarendar, Malladi, Srinivas Reddy
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Carboxylates
Chemical synthesis
Ethanol
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container_issue 5
container_start_page 2830
container_title Journal of heterocyclic chemistry
container_volume 54
creator Saini, Ramakrishna
Dharavath, Nagaraju
Eligeti, Rajanarendar
Malladi, Srinivas Reddy
description A series of novel isoxazolyl‐4‐(2‐oxo‐2,3‐dihydro‐1H‐3‐indolyl)pyrrole‐3‐carboxylates (17a–i) were synthesized by a three‐component reaction of 4‐amino‐3‐methyl‐5‐styrylisoxazole 14, β‐keto ester 15, and 3‐phenacylideneoxindole 16, in the presence of CAN catalyst in ethanol. The structures of the synthesized compounds have been established on the basis of spectral and analytical data. The title compounds 17a–i were evaluated for their anti‐inflammatory activity. Compounds 17b and 17c exhibited potent anti‐inflammatory activity as that of standard drug.
doi_str_mv 10.1002/jhet.2888
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subjects Carboxylates
Chemical synthesis
Ethanol
title Synthesis, Characterization, and Anti‐inflammatory Activity of Novel Isoxazolyl‐4‐(2‐oxo‐2,3‐dihydro‐1H‐3‐indolyl)pyrrole‐3‐carboxylates
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