Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation

Dopamine (DA) neurons in the ventral tegmental area (VTA) are predicted to play important roles in reward. In pharmacological studies, the rewarding effects of methamphetamine are mediated by DA neurons localized in the VTA. The nucleus accumbens (NAc) and medial prefrontal cortices (mPFC) are the m...

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Veröffentlicht in:	Metabolic brain disease 2017-10, Vol.32 (5), p.1491-1502
Hauptverfasser:	Han, Xiao, Jing, Man-yi, Zhao, Tai-yun, Wu, Ning, Song, Rui, Li, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines Animal behavior Animals Behavior, Animal - physiology Biochemistry Biomedical and Life Sciences Biomedicine Conditioning, Operant - drug effects Conditioning, Operant - physiology Dopamine Dopamine Agents - administration & dosage Dopamine Agents - pharmacology Dopamine Plasma Membrane Transport Proteins - genetics Dopamine transporter Dopaminergic Neurons - physiology Dose-Response Relationship, Drug Excitation Forecasting Locomotion Male Metabolic Diseases Methamphetamine Methamphetamine - administration & dosage Methamphetamine - pharmacology Mice Mice, Transgenic Motor Activity - drug effects Mouse devices Neural Pathways - diagnostic imaging Neural Pathways - physiology Neurology Neurons Neurosciences Nuclei Nucleus accumbens Nucleus Accumbens - diagnostic imaging Nucleus Accumbens - physiology Oncology Opsins Optogenetics Original Article Pharmacology Photic Stimulation Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - physiology Reinforcement Rodents Self Stimulation Stimulation Transgenic mice Ventral Tegmental Area - diagnostic imaging Ventral Tegmental Area - physiology Ventral tegmentum
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