Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease

RationaleCellular senescence is observed in the lungs of patients with COPD and may contribute to the disease pathogenesis. Growth differentiation factor 11 (GDF11) belongs to the transforming growth factor β superfamily and was recently reported to be a circulating protein that may have rejuvenatin...

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Veröffentlicht in:	Thorax 2017-10, Vol.72 (10), p.893-904
Hauptverfasser:	Onodera, Katsuhiro, Sugiura, Hisatoshi, Yamada, Mitsuhiro, Koarai, Akira, Fujino, Naoya, Yanagisawa, Satoru, Tanaka, Rie, Numakura, Tadahisa, Togo, Shinsaku, Sato, Kei, Kyogoku, Yorihiko, Hashimoto, Yuichiro, Okazaki, Tatsuma, Tamada, Tsutomu, Kobayashi, Seiichi, Yanai, Masaru, Miura, Motohiko, Hoshikawa, Yasushi, Okada, Yoshinori, Suzuki, Satoshi, Ichinose, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aging Animals Blotting, Western Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Cellular Senescence Chronic obstructive pulmonary disease Disease Disease Models, Animal Emphysema Ethics Experiments Female Fibroblasts Growth Differentiation Factors - metabolism Growth Differentiation Factors - pharmacology Growth factors Hospitals Humans Immunohistochemistry Lung cancer Male Mice Mortality Oxidative stress Pathogenesis Plasma Pulmonary Disease, Chronic Obstructive - metabolism Respiratory Function Tests Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Senescence Smoke - adverse effects Smoking Studies
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