Assessment of the visual acuity, contrast sensitivity, color vision and visual integration in the Alzheimer's Disease progression according to the scale GDS
Purpose Alzheimer's disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain with cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The process is estimated to begin years before the appearance of clinical symptom...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2017-09, Vol.95 (S259), p.n/a |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Salobrar‐Garcia, E. Hurtado, L. Lopez‐Cuenca, I. de Hoz, R. Salazar, J.J. Ramirez, A.I. Yubero, R. Gil, P. Ramirez, J.M. |
| description | Purpose
Alzheimer's disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain with cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The process is estimated to begin years before the appearance of clinical symptoms. The aim of this work was to investigate the potential use of ophthalmological psychophysical tests as AD follow‐up.
Methods
Twenty‐six mild AD patients, 12 moderate AD and 32 controls underwent visual acuity (VA), contrast sensitivity (CS), colour perception tests and perception visual test (PDT). All patients were classified according the Global Deteriorate Scale (GDS).
Results
In comparison with control: i) patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the blue colour perception and in PDT; ii) patients with moderate AD showed the same result as the mild AD, compared with controls, furthermore a significant increase of the total number of errors in the colour test (p 0.05) but significant differences in the colour perception (total number of errors and unspecific blue axis errors) (p |
| doi_str_mv | 10.1111/j.1755-3768.2017.0T021 |
| format | Article |
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Alzheimer's disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain with cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The process is estimated to begin years before the appearance of clinical symptoms. The aim of this work was to investigate the potential use of ophthalmological psychophysical tests as AD follow‐up.
Methods
Twenty‐six mild AD patients, 12 moderate AD and 32 controls underwent visual acuity (VA), contrast sensitivity (CS), colour perception tests and perception visual test (PDT). All patients were classified according the Global Deteriorate Scale (GDS).
Results
In comparison with control: i) patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the blue colour perception and in PDT; ii) patients with moderate AD showed the same result as the mild AD, compared with controls, furthermore a significant increase of the total number of errors in the colour test (p < 0.05 in all instances). In comparison with mild AD, moderate AD patients had no statistical differences in CS, VA and PDT (p > 0.05) but significant differences in the colour perception (total number of errors and unspecific blue axis errors) (p < 0.05).
Conclusions
In comparison with the control group, patients with mild and moderate AD presented a statistically significant decrease in CS, for all the spatial frequencies (the higher the spatial frequency, the greater the loss of CS perception), and in the colour perception. Therefore AD patients, show alterations in the M, P, and K visual pathways. Psychophysical tests could be useful tools to diagnose support and follow‐up in mild AD.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2017.0T021</identifier><language>eng</language><publisher>Malden: Wiley Subscription Services, Inc</publisher><subject>Acuity ; Alzheimer's disease ; Atrophy ; Brain ; Color ; Color vision ; Cortex ; Frequency dependence ; Integration ; Neurodegenerative diseases ; Perception ; Plaques ; Psychophysics ; Sensitivity ; Spatial discrimination ; Statistical analysis ; Test procedures ; Visual acuity ; Visual pathways ; Visual perception</subject><ispartof>Acta ophthalmologica (Oxford, England), 2017-09, Vol.95 (S259), p.n/a</ispartof><rights>2017 The Authors Acta Ophthalmologica © 2017 Acta Ophthalmologica Scandinavica Foundation</rights><rights>Copyright © 2017 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2017.0T021$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45575,46833</link.rule.ids></links><search><creatorcontrib>Salobrar‐Garcia, E.</creatorcontrib><creatorcontrib>Hurtado, L.</creatorcontrib><creatorcontrib>Lopez‐Cuenca, I.</creatorcontrib><creatorcontrib>de Hoz, R.</creatorcontrib><creatorcontrib>Salazar, J.J.</creatorcontrib><creatorcontrib>Ramirez, A.I.</creatorcontrib><creatorcontrib>Yubero, R.</creatorcontrib><creatorcontrib>Gil, P.</creatorcontrib><creatorcontrib>Ramirez, J.M.</creatorcontrib><title>Assessment of the visual acuity, contrast sensitivity, color vision and visual integration in the Alzheimer's Disease progression according to the scale GDS</title><title>Acta ophthalmologica (Oxford, England)</title><description>Purpose
Alzheimer's disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain with cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The process is estimated to begin years before the appearance of clinical symptoms. The aim of this work was to investigate the potential use of ophthalmological psychophysical tests as AD follow‐up.
Methods
Twenty‐six mild AD patients, 12 moderate AD and 32 controls underwent visual acuity (VA), contrast sensitivity (CS), colour perception tests and perception visual test (PDT). All patients were classified according the Global Deteriorate Scale (GDS).
Results
In comparison with control: i) patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the blue colour perception and in PDT; ii) patients with moderate AD showed the same result as the mild AD, compared with controls, furthermore a significant increase of the total number of errors in the colour test (p < 0.05 in all instances). In comparison with mild AD, moderate AD patients had no statistical differences in CS, VA and PDT (p > 0.05) but significant differences in the colour perception (total number of errors and unspecific blue axis errors) (p < 0.05).
Conclusions
In comparison with the control group, patients with mild and moderate AD presented a statistically significant decrease in CS, for all the spatial frequencies (the higher the spatial frequency, the greater the loss of CS perception), and in the colour perception. Therefore AD patients, show alterations in the M, P, and K visual pathways. Psychophysical tests could be useful tools to diagnose support and follow‐up in mild AD.</description><subject>Acuity</subject><subject>Alzheimer's disease</subject><subject>Atrophy</subject><subject>Brain</subject><subject>Color</subject><subject>Color vision</subject><subject>Cortex</subject><subject>Frequency dependence</subject><subject>Integration</subject><subject>Neurodegenerative diseases</subject><subject>Perception</subject><subject>Plaques</subject><subject>Psychophysics</subject><subject>Sensitivity</subject><subject>Spatial discrimination</subject><subject>Statistical analysis</subject><subject>Test procedures</subject><subject>Visual acuity</subject><subject>Visual pathways</subject><subject>Visual perception</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkcFOAjEQhjdGExF9BdPEgxdZ22Vpl8QLAUUTEg9q4q0p3SmULC12CgafxYd1F5SzvbT5-38zk_mT5JLRlNXndpEy0et1uoIXaUaZSOkrzdhR0jrIx4d37_00OUNcUMoZ53kr-R4gAuISXCTekDgHsrG4VhVRem3j9oZo72JQGAmCQxvt5letfGis1juiXPlHWRdhFlRsZOt29QbV1xzsEsI1kpFFUAhkFfws1H13tNY-lNbNSPQ7ALWqgIxHL-fJiVEVwsXv3U7eHu5fh4-dyfP4aTiYdDQTnHW6xrB-UTKdU8Z7igqWMQPTXEzznPVVbpQuMkqVmvaNKssCoAuFnpoMMlFy1u-2k6t93XqsjzVglAu_Dq5uKetfnuVFJkTt4nuXDh4xgJGrYJcqbCWjsklCLmSzZtmsXDZJyF0SNXi3Bz9tBdt_UnLw_LLHfwBwlJHd</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Salobrar‐Garcia, E.</creator><creator>Hurtado, L.</creator><creator>Lopez‐Cuenca, I.</creator><creator>de Hoz, R.</creator><creator>Salazar, J.J.</creator><creator>Ramirez, A.I.</creator><creator>Yubero, R.</creator><creator>Gil, P.</creator><creator>Ramirez, J.M.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>201709</creationdate><title>Assessment of the visual acuity, contrast sensitivity, color vision and visual integration in the Alzheimer's Disease progression according to the scale GDS</title><author>Salobrar‐Garcia, E. ; Hurtado, L. ; Lopez‐Cuenca, I. ; de Hoz, R. ; Salazar, J.J. ; Ramirez, A.I. ; Yubero, R. ; Gil, P. ; Ramirez, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1761-3ff198d1c40165a07121feb47b4419a4fac8200aab9fadd8ee3e8cbf2e27d6193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acuity</topic><topic>Alzheimer's disease</topic><topic>Atrophy</topic><topic>Brain</topic><topic>Color</topic><topic>Color vision</topic><topic>Cortex</topic><topic>Frequency dependence</topic><topic>Integration</topic><topic>Neurodegenerative diseases</topic><topic>Perception</topic><topic>Plaques</topic><topic>Psychophysics</topic><topic>Sensitivity</topic><topic>Spatial discrimination</topic><topic>Statistical analysis</topic><topic>Test procedures</topic><topic>Visual acuity</topic><topic>Visual pathways</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salobrar‐Garcia, E.</creatorcontrib><creatorcontrib>Hurtado, L.</creatorcontrib><creatorcontrib>Lopez‐Cuenca, I.</creatorcontrib><creatorcontrib>de Hoz, R.</creatorcontrib><creatorcontrib>Salazar, J.J.</creatorcontrib><creatorcontrib>Ramirez, A.I.</creatorcontrib><creatorcontrib>Yubero, R.</creatorcontrib><creatorcontrib>Gil, P.</creatorcontrib><creatorcontrib>Ramirez, J.M.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salobrar‐Garcia, E.</au><au>Hurtado, L.</au><au>Lopez‐Cuenca, I.</au><au>de Hoz, R.</au><au>Salazar, J.J.</au><au>Ramirez, A.I.</au><au>Yubero, R.</au><au>Gil, P.</au><au>Ramirez, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the visual acuity, contrast sensitivity, color vision and visual integration in the Alzheimer's Disease progression according to the scale GDS</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><date>2017-09</date><risdate>2017</risdate><volume>95</volume><issue>S259</issue><epage>n/a</epage><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
Alzheimer's disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain with cortical atrophy most pronounced in the medial temporal and posterior temporoparietal regions. The process is estimated to begin years before the appearance of clinical symptoms. The aim of this work was to investigate the potential use of ophthalmological psychophysical tests as AD follow‐up.
Methods
Twenty‐six mild AD patients, 12 moderate AD and 32 controls underwent visual acuity (VA), contrast sensitivity (CS), colour perception tests and perception visual test (PDT). All patients were classified according the Global Deteriorate Scale (GDS).
Results
In comparison with control: i) patients with mild AD presented a significant decrease in the VA, in the CS (for all the spatial frequencies), in the blue colour perception and in PDT; ii) patients with moderate AD showed the same result as the mild AD, compared with controls, furthermore a significant increase of the total number of errors in the colour test (p < 0.05 in all instances). In comparison with mild AD, moderate AD patients had no statistical differences in CS, VA and PDT (p > 0.05) but significant differences in the colour perception (total number of errors and unspecific blue axis errors) (p < 0.05).
Conclusions
In comparison with the control group, patients with mild and moderate AD presented a statistically significant decrease in CS, for all the spatial frequencies (the higher the spatial frequency, the greater the loss of CS perception), and in the colour perception. Therefore AD patients, show alterations in the M, P, and K visual pathways. Psychophysical tests could be useful tools to diagnose support and follow‐up in mild AD.</abstract><cop>Malden</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/j.1755-3768.2017.0T021</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acuity Alzheimer's disease Atrophy Brain Color Color vision Cortex Frequency dependence Integration Neurodegenerative diseases Perception Plaques Psychophysics Sensitivity Spatial discrimination Statistical analysis Test procedures Visual acuity Visual pathways Visual perception |
| title | Assessment of the visual acuity, contrast sensitivity, color vision and visual integration in the Alzheimer's Disease progression according to the scale GDS |
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