Chronic exposure to TNF[alpha] impairs RPE barrier and immunosuppressive functions

Purpose The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important roles in the outer blood-retinal barrier and subretinal immune suppression. Failure of RPE functions and inflammation have both been hypothesized to play a role in the pathophysiology of age related macular...

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Veröffentlicht in:	Acta ophthalmologica (Oxford, England) England), 2017-09, Vol.95 (S259)
Hauptverfasser:	Touhami, S, Beguier, F, Augustin, S, Reichman, S, Goureau, O, Nandrot, E, Guillonneau, X, Bodaghi, B, Sennlaub, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Barriers Cell culture Cell morphology Cell number Cell size Chronic exposure Cytology Degeneration Epithelium Gene expression Immunosuppression Long-term effects Macular degeneration Monocytes Morphology Otx2 protein Phagocytosis Retina Retinal pigment epithelium Stimulation Tumor necrosis factor Visual perception Zonula occludens-1 protein
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