p-NO^sub 2^-Bn-H^sub 4^ neunpa and H^sub 4^neunpa-Trastuzumab: Bifunctional Chelator for Radiometalpharmaceuticals and ^sup 111^ In Immuno-Single Photon Emission Computed Tomography Imaging

Potentially nonadentate (N5O4) bifunctional chelator p-SCN-Bn-H4neunpa and its immunoconjugate H4neunpa-trastuzumab for 111In radiolabeling are synthesized. The ability of p-SCN-Bn-H4neunpa and H4neunpa-trastuzumab to quantitatively radiolabel 111InCl3 at an ambient temperature within 15 or 30 min,...

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Veröffentlicht in:	Bioconjugate chemistry 2017-08, Vol.28 (8), p.2145
Hauptverfasser:	Spreckelmeyer, Sarah, Ramogida, Caterina F, Rousseau, Julie, Arane, Karen, Bratanovic, Ivica, Colpo, Nadine, Jermilova, Una, Dias, Gemma M, Dude, Iulia, Jaraquemada-Peláez, Maria de Guadalupe, Bénard, François, Schaffer, Paul, Orvig, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambient temperature Atoms & subatomic particles Computation Computed tomography Diethylenetriamine pentaacetic acid Emission analysis Emissions Immunoconjugates In vitro methods and tests In vivo methods and tests Medical imaging Mice Monoclonal antibodies Nitrogen dioxide Pharmaceuticals Photon emission Radioactive materials Rodents Single photon emission computed tomography Stability Trastuzumab
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