A fusion protein of interleukin‐4 and interleukin‐10 protects against blood‐induced cartilage damage in vitro and in vivo

Essentials Targeted treatment for hemophilic arthropathy, still causing significant morbidity, is lacking. This study evaluates the efficacy of a fusion of protein of interleukin(IL)‐4 and IL‐10. In vitro the fusion protein prevents blood‐induced cartilage damage in a dose‐dependent manner. In hemop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of thrombosis and haemostasis 2017-09, Vol.15 (9), p.1788-1798
Hauptverfasser:	van Vulpen, L. F. D., Popov‐Celeketic, J., van Meegeren, M. E. R., Coeleveld, K., van Laar, J. M., Hack, C. E., Schutgens, R. E. G., Mastbergen, S. C., Lafeber, F. P. J. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Bioavailability Bleeding Blood Cartilage Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cartilage, Articular - pathology Cytokines Degeneration Disease Models, Animal Dose-Response Relationship, Drug Explants Factor VIII - genetics Factor VIII - metabolism Female Fusion protein Genetic Predisposition to Disease hemarthrosis Hemarthrosis - blood Hemarthrosis - pathology Hemarthrosis - prevention & control Hemophilia hemophilia A Hemophilia A - blood Hemophilia A - drug therapy Hemophilia A - genetics Humans Inflammation Mediators - metabolism Interleukin 1 Interleukin 10 Interleukin 4 Interleukin 6 Interleukin-1beta - metabolism Interleukin-6 - metabolism investigational joint diseases Macrophages Male Mice, Knockout Middle Aged Monocytes Morbidity Phenotype Proteins Proteoglycans - metabolism Recombinant Fusion Proteins - pharmacology Rodents Synovitis therapies Time Factors Tissue Culture Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!