Efficiency of ascorbic acid against oxidative stress-induced dimethoate toxicity in fish, Capoeta capoeta [Guldenstaedt, 1773]

The main objective of the present study was to evaluate the effect of ascorbic acid against oxidative stress-induced by dimethoate in Capoeta capoeta. The fish caught in Kars Creek were randomized in four equal groups and acclimatized in separate tanks. The fish were kept in tanks for 10 days as follows: Group I (control) was kept in normal water, Group II, III and IV were kept in separate tanks containing 2 mgľdimethoate and 2 mgľ dimethoate plus 100 mgľ ascorbic acid and ascorbic acid. The level of total sialic acid, total antioxidant status and total oxidant status in fish serum were analyzed. Total sialic acid level of Group III was found to be lower than the level of Group II (P< 0.05), there were no statistically important differences between these two groups in total antioxidant status and oxidant status. In gills, intensive cartilage degenerations and mononuclear cell infiltrations in group II and III were observed. It was found that toxic effects of dimethoate in group III decreased. Ascorbic acid in fish exposed to dimethoate reduced the level of total sialic acid and degenerations in lamellae of gills, it had no significant effect on the oxidative stress response.