An Aγ-globin G->A gene polymorphism associated with Beta039 thalassemia globin gene and high fetal hemoglobin production

Background Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI, BCL11A and MYB polymorphisms) has...

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Veröffentlicht in:	BMC medical genetics 2017-01, Vol.18
Hauptverfasser:	Breveglieri, Giulia, Bianchi, Nicoletta, Cosenza, Lucia Carmela, Gamberini, Maria Rita, Chiavilli, Francesco, Zuccato, Cristina, Montagner, Giulia, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Gambari, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Deoxyribonucleic acid DNA DNA sequencing Expectancy Fetuses Gene expression Gene polymorphism Genomics Hemoglobin Hydroxyurea Mutation Patients Studies Thalassemia
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