Dynamic Kinetic Resolution of Ethyl 1,2,3,4-Tetrahydro-[beta]-carboline-1-carboxylate: Use of Different Hydrolases for Stereocomplementary Processes

Both enantiomers of 1,2,3,4-tetrahydro-[beta]-carboline-1-carboxylic acid have been prepared by dynamic kinetic resolution of the corresponding ethyl ester (±)-1. CAL-B-catalysed hydrolysis of (±)-1·HCl in NH4OAc buffer (pH 8.0, 30 °C) provided amino acid (R)-2·HCl with 98% ee and 90% yield in 20 mi...

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Veröffentlicht in:	European journal of organic chemistry 2017-09, Vol.2017 (32), p.4713
Hauptverfasser:	Megyesi, Rita, Mandi, Attila, Kurtan, Tibor, ro, Enik, Fulop, Ferenc
Format:	Artikel
Sprache:	eng
Schlagworte:	Buffers Dichroism Enantiomers Hydrolysis Optical properties Optical rotation Selectivity
Online-Zugang:	Volltext
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