Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model

Ex vivo normothermic lung perfusion (EVLP) is a novel platform and method developed to facilitate functional assessment and implementation of advanced therapies for donor lungs prior to transplantation. This study aimed to determine the safety and immunological and functional benefits of ex vivo ade...

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Veröffentlicht in:	Human gene therapy 2017-09, Vol.28 (9), p.757-765
Hauptverfasser:	Machuca, Tiago N, Cypel, Marcelo, Bonato, Riccardo, Yeung, Jonathan C, Chun, Yi-Min, Juvet, Stephen, Guan, Zehong, Hwang, David M, Chen, Manyin, Saito, Tomohito, Harmantas, Constantine, Davidson, Beverly L, Waddell, Thomas K, Liu, Mingyao, Keshavjee, Shaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adenoviridae - genetics Allografts Animals Cryopreservation Disease Models, Animal Enzyme-linked immunosorbent assay Gas exchange Gene therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - genetics Graft Survival - genetics Hematology Humans Immune response Immunology Immunosuppression Interferon Interleukin 10 Interleukin-10 - genetics Interleukins Ischemia Lung - metabolism Lung transplantation Lung Transplantation - methods Lungs Lymph nodes Lymphocytes Male Perfusion Perfusion - methods Peripheral blood Plasma levels Reperfusion Injury - genetics Respiratory function Safety Survival Swine Tissue Donors Toxicity Transplantation Transplants & implants Xenografts
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