POSS-modified PEG Adhesives for Wound Closure
PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesive...
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| Veröffentlicht in: | Chinese journal of polymer science 2017-10, Vol.35 (10), p.1231-1242 |
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| container_title | Chinese journal of polymer science |
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| creator | Bu, Ya-zhong Sun, Guo-fei Zhang, Li-cheng Liu, Jian-heng Yang, Fei Tang, Pei-fu Wu, De-cheng |
| description | PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure. |
| doi_str_mv | 10.1007/s10118-017-1958-x |
| format | Article |
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In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. 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In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.</description><subject>Adhesive strength</subject><subject>Adhesives</subject><subject>Biocompatibility</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter Physics</subject><subject>Healing</subject><subject>In vitro methods and tests</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Inflammatory response</subject><subject>Polymer Sciences</subject><subject>POSS</subject><subject>Toxicity</subject><subject>伤口</subject><subject>体外细胞毒性</subject><subject>改性</subject><subject>生物相容性</subject><subject>粘合剂</subject><subject>细胞生长</subject><subject>聚乙二醇</subject><issn>0256-7679</issn><issn>1439-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PAjEURRujiYj-AHcTXVdfp9OvJSGIJiSQoHHZjG0HhsAUWsbAv7dkiHHl6m3uufflIHRP4IkAiOdIgBCJgQhMFJP4cIF6pKAK8xzoJepBzjgWXKhrdBPjCoAXgokewrPpfI433tZV7Ww2G42zgV26WH-7mFU-ZJ--bWw2XPvYBneLrqpyHd3d-fbRx8voffiKJ9Px23AwwYYWdI-ZtDlAKSpRKSuVYqWgYBXLS_plXHrI2IIU3AAwCUaCMwRkLrmjCVC0on302PVug9-1Lu71yrehSZOaKEo5F6IQKUW6lAk-xuAqvQ31pgxHTUCfrOjOik5W9MmKPiQm75iYss3ChT_N_0AP56Glbxa7xP0ucUFJUiso_QFRo221</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Bu, Ya-zhong</creator><creator>Sun, Guo-fei</creator><creator>Zhang, Li-cheng</creator><creator>Liu, Jian-heng</creator><creator>Yang, Fei</creator><creator>Tang, Pei-fu</creator><creator>Wu, De-cheng</creator><general>Chinese Chemical Society and Institute of Chemistry, CAS</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171001</creationdate><title>POSS-modified PEG Adhesives for Wound Closure</title><author>Bu, Ya-zhong ; Sun, Guo-fei ; Zhang, Li-cheng ; Liu, Jian-heng ; Yang, Fei ; Tang, Pei-fu ; Wu, De-cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-58d200a7f7f9d8995a730d952a3bce203cd4146c00580c80ec108286e37f993f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adhesive strength</topic><topic>Adhesives</topic><topic>Biocompatibility</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Condensed Matter Physics</topic><topic>Healing</topic><topic>In vitro methods and tests</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Inflammatory response</topic><topic>Polymer Sciences</topic><topic>POSS</topic><topic>Toxicity</topic><topic>伤口</topic><topic>体外细胞毒性</topic><topic>改性</topic><topic>生物相容性</topic><topic>粘合剂</topic><topic>细胞生长</topic><topic>聚乙二醇</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bu, Ya-zhong</creatorcontrib><creatorcontrib>Sun, Guo-fei</creatorcontrib><creatorcontrib>Zhang, Li-cheng</creatorcontrib><creatorcontrib>Liu, Jian-heng</creatorcontrib><creatorcontrib>Yang, Fei</creatorcontrib><creatorcontrib>Tang, Pei-fu</creatorcontrib><creatorcontrib>Wu, De-cheng</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><jtitle>Chinese journal of polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bu, Ya-zhong</au><au>Sun, Guo-fei</au><au>Zhang, Li-cheng</au><au>Liu, Jian-heng</au><au>Yang, Fei</au><au>Tang, Pei-fu</au><au>Wu, De-cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>POSS-modified PEG Adhesives for Wound Closure</atitle><jtitle>Chinese journal of polymer science</jtitle><stitle>Chin J Polym Sci</stitle><addtitle>Chinese Journal of Polymer Science</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>35</volume><issue>10</issue><spage>1231</spage><epage>1242</epage><pages>1231-1242</pages><issn>0256-7679</issn><eissn>1439-6203</eissn><abstract>PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. 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| language | eng |
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| subjects | Adhesive strength Adhesives Biocompatibility Cell adhesion Cell adhesion & migration Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Condensed Matter Physics Healing In vitro methods and tests Industrial Chemistry/Chemical Engineering Inflammatory response Polymer Sciences POSS Toxicity 伤口 体外细胞毒性 改性 生物相容性 粘合剂 细胞生长 聚乙二醇 |
| title | POSS-modified PEG Adhesives for Wound Closure |
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