Effect of rutin on diabetic‐induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats
The present study aimed to investigate effects of rutin on diabetic‐induced impairments of sexual behaviour, spermatogenesis and oxidative testicular damage. Diabetes was induced by a single injection of STZ (65 mg/kg) in male adult Wistar rats. Two weeks later, rutin (50 and 100 mg kg−1 day−1) was...
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| Veröffentlicht in: | Andrologia 2017-10, Vol.49 (8), p.e12737-n/a |
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| creator | Al‐Roujeaie, A. S. Abuohashish, H. M. Ahmed, M. M. Alkhamees, O. A. |
| description | The present study aimed to investigate effects of rutin on diabetic‐induced impairments of sexual behaviour, spermatogenesis and oxidative testicular damage. Diabetes was induced by a single injection of STZ (65 mg/kg) in male adult Wistar rats. Two weeks later, rutin (50 and 100 mg kg−1 day−1) was treated to normal and diabetic rats for 5 weeks. Sexual behaviour of the animals was observed by taking stimulus females. At the end of the study, sperm count, motility and viability were recorded. Serum levels of glucose, inflammatory markers and testosterone were also estimated. In penile tissue, cGMP levels were measured, while lipid peroxidation and antioxidant molecules and enzyme activities were determined. Finally, histopathological changes were evaluated in a cross‐section of testis. Diabetic‐induced alterations in male sexual behaviour and sperm count, motility and viability were markedly corrected following 5 weeks of rutin treatment to the diabetic animals. Rutin also attenuated the inhibited serum testosterone and penile cGMP content, while improved diabetic‐associated inflammation and testicular lipid peroxidation and oxidative stress. Histopathological evaluation revealed damaged testicular tissues in diabetic rats, which was protected following rutin treatment. In conclusion, treatment with rutin improved sexual functionality and also protects against diabetic‐induced testicular damage. |
| doi_str_mv | 10.1111/and.12737 |
| format | Article |
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S. ; Abuohashish, H. M. ; Ahmed, M. M. ; Alkhamees, O. A.</creator><creatorcontrib>Al‐Roujeaie, A. S. ; Abuohashish, H. M. ; Ahmed, M. M. ; Alkhamees, O. A.</creatorcontrib><description>The present study aimed to investigate effects of rutin on diabetic‐induced impairments of sexual behaviour, spermatogenesis and oxidative testicular damage. Diabetes was induced by a single injection of STZ (65 mg/kg) in male adult Wistar rats. Two weeks later, rutin (50 and 100 mg kg−1 day−1) was treated to normal and diabetic rats for 5 weeks. Sexual behaviour of the animals was observed by taking stimulus females. At the end of the study, sperm count, motility and viability were recorded. Serum levels of glucose, inflammatory markers and testosterone were also estimated. In penile tissue, cGMP levels were measured, while lipid peroxidation and antioxidant molecules and enzyme activities were determined. Finally, histopathological changes were evaluated in a cross‐section of testis. Diabetic‐induced alterations in male sexual behaviour and sperm count, motility and viability were markedly corrected following 5 weeks of rutin treatment to the diabetic animals. Rutin also attenuated the inhibited serum testosterone and penile cGMP content, while improved diabetic‐associated inflammation and testicular lipid peroxidation and oxidative stress. Histopathological evaluation revealed damaged testicular tissues in diabetic rats, which was protected following rutin treatment. In conclusion, treatment with rutin improved sexual functionality and also protects against diabetic‐induced testicular damage.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12737</identifier><identifier>PMID: 27785836</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Androgens ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Cell Survival - drug effects ; Cyclic GMP ; Cyclic GMP - metabolism ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - metabolism ; Disease Models, Animal ; Erectile dysfunction ; Erectile Dysfunction - drug therapy ; Erectile Dysfunction - etiology ; Erectile Dysfunction - metabolism ; Inflammation ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Motility ; Oxidative stress ; Oxidative Stress - drug effects ; Penis ; Penis - drug effects ; Penis - metabolism ; Rats ; Rats, Wistar ; Rodents ; Rutin ; Rutin - pharmacology ; Rutin - therapeutic use ; Serum levels ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Sperm ; Sperm Count ; Sperm Motility - drug effects ; Spermatogenesis ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; streptozotocin ; Testes ; testicular damage ; Testis - drug effects ; Testis - metabolism ; Testosterone ; Testosterone - blood</subject><ispartof>Andrologia, 2017-10, Vol.49 (8), p.e12737-n/a</ispartof><rights>2016 Blackwell Verlag GmbH</rights><rights>2016 Blackwell Verlag GmbH.</rights><rights>Copyright © 2017 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-21735af0b7c18e46ef7e4d7456530f1217180ab655effa61f6ee537afe1160b33</citedby><cites>FETCH-LOGICAL-c3887-21735af0b7c18e46ef7e4d7456530f1217180ab655effa61f6ee537afe1160b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12737$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12737$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27785836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Roujeaie, A. S.</creatorcontrib><creatorcontrib>Abuohashish, H. M.</creatorcontrib><creatorcontrib>Ahmed, M. M.</creatorcontrib><creatorcontrib>Alkhamees, O. A.</creatorcontrib><title>Effect of rutin on diabetic‐induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>The present study aimed to investigate effects of rutin on diabetic‐induced impairments of sexual behaviour, spermatogenesis and oxidative testicular damage. Diabetes was induced by a single injection of STZ (65 mg/kg) in male adult Wistar rats. Two weeks later, rutin (50 and 100 mg kg−1 day−1) was treated to normal and diabetic rats for 5 weeks. Sexual behaviour of the animals was observed by taking stimulus females. At the end of the study, sperm count, motility and viability were recorded. Serum levels of glucose, inflammatory markers and testosterone were also estimated. In penile tissue, cGMP levels were measured, while lipid peroxidation and antioxidant molecules and enzyme activities were determined. Finally, histopathological changes were evaluated in a cross‐section of testis. Diabetic‐induced alterations in male sexual behaviour and sperm count, motility and viability were markedly corrected following 5 weeks of rutin treatment to the diabetic animals. Rutin also attenuated the inhibited serum testosterone and penile cGMP content, while improved diabetic‐associated inflammation and testicular lipid peroxidation and oxidative stress. Histopathological evaluation revealed damaged testicular tissues in diabetic rats, which was protected following rutin treatment. In conclusion, treatment with rutin improved sexual functionality and also protects against diabetic‐induced testicular damage.</description><subject>Androgens</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Cell Survival - drug effects</subject><subject>Cyclic GMP</subject><subject>Cyclic GMP - metabolism</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Disease Models, Animal</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - drug therapy</subject><subject>Erectile Dysfunction - etiology</subject><subject>Erectile Dysfunction - metabolism</subject><subject>Inflammation</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Motility</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Penis</subject><subject>Penis - drug effects</subject><subject>Penis - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Rutin</subject><subject>Rutin - pharmacology</subject><subject>Rutin - therapeutic use</subject><subject>Serum levels</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatogenesis</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>streptozotocin</subject><subject>Testes</subject><subject>testicular damage</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EolXpggsgS6xYpLXjOE7ZVaU8pApYwDpykrHk0jrFToq64wickZMwfcCO2diyP_-e-Qg552zAsYbaVQMeK6GOSJcnYhSxWMXHpMsEE1Ei01GH9EOYM6xEKpUkp6QTK5XJTKRdsp4aA2VDa0N921hHa0crqwtobPn9-WVd1ZZQUfAI2QXQahNM63Bfu2v6XIdgCzy1bl0v1rAEt0tqIODzdqE9LWy91P4NfECILjXCXjfhjJwYvQjQP6w98no7fZncR7Onu4fJeBaVIstUFHMlpDasUCXPIEnBKEgqhVNJwQzHa54xXaRSgjE65SYFkEJpA5ynrBCiRy73uStfv7fYVj6vW-_wy5yPhIiliOMtdbWnSo8TeTD5yltse5Nzlm8l5yg530lG9uKQ2BZLqP7IX6UIDPfAB_ra_J-Ujx9v9pE__BqH7A</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Al‐Roujeaie, A. S.</creator><creator>Abuohashish, H. M.</creator><creator>Ahmed, M. M.</creator><creator>Alkhamees, O. A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope></search><sort><creationdate>201710</creationdate><title>Effect of rutin on diabetic‐induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats</title><author>Al‐Roujeaie, A. S. ; Abuohashish, H. M. ; Ahmed, M. M. ; Alkhamees, O. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-21735af0b7c18e46ef7e4d7456530f1217180ab655effa61f6ee537afe1160b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Androgens</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Cell Survival - drug effects</topic><topic>Cyclic GMP</topic><topic>Cyclic GMP - metabolism</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Disease Models, Animal</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - drug therapy</topic><topic>Erectile Dysfunction - etiology</topic><topic>Erectile Dysfunction - metabolism</topic><topic>Inflammation</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Motility</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Penis</topic><topic>Penis - drug effects</topic><topic>Penis - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Rutin</topic><topic>Rutin - pharmacology</topic><topic>Rutin - therapeutic use</topic><topic>Serum levels</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatogenesis</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>streptozotocin</topic><topic>Testes</topic><topic>testicular damage</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Roujeaie, A. S.</creatorcontrib><creatorcontrib>Abuohashish, H. M.</creatorcontrib><creatorcontrib>Ahmed, M. M.</creatorcontrib><creatorcontrib>Alkhamees, O. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Roujeaie, A. S.</au><au>Abuohashish, H. M.</au><au>Ahmed, M. M.</au><au>Alkhamees, O. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of rutin on diabetic‐induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2017-10</date><risdate>2017</risdate><volume>49</volume><issue>8</issue><spage>e12737</spage><epage>n/a</epage><pages>e12737-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>The present study aimed to investigate effects of rutin on diabetic‐induced impairments of sexual behaviour, spermatogenesis and oxidative testicular damage. Diabetes was induced by a single injection of STZ (65 mg/kg) in male adult Wistar rats. Two weeks later, rutin (50 and 100 mg kg−1 day−1) was treated to normal and diabetic rats for 5 weeks. Sexual behaviour of the animals was observed by taking stimulus females. At the end of the study, sperm count, motility and viability were recorded. Serum levels of glucose, inflammatory markers and testosterone were also estimated. In penile tissue, cGMP levels were measured, while lipid peroxidation and antioxidant molecules and enzyme activities were determined. Finally, histopathological changes were evaluated in a cross‐section of testis. Diabetic‐induced alterations in male sexual behaviour and sperm count, motility and viability were markedly corrected following 5 weeks of rutin treatment to the diabetic animals. Rutin also attenuated the inhibited serum testosterone and penile cGMP content, while improved diabetic‐associated inflammation and testicular lipid peroxidation and oxidative stress. Histopathological evaluation revealed damaged testicular tissues in diabetic rats, which was protected following rutin treatment. In conclusion, treatment with rutin improved sexual functionality and also protects against diabetic‐induced testicular damage.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27785836</pmid><doi>10.1111/and.12737</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Androgens Animals Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Cell Survival - drug effects Cyclic GMP Cyclic GMP - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Erectile dysfunction Erectile Dysfunction - drug therapy Erectile Dysfunction - etiology Erectile Dysfunction - metabolism Inflammation Lipid peroxidation Lipid Peroxidation - drug effects Male Motility Oxidative stress Oxidative Stress - drug effects Penis Penis - drug effects Penis - metabolism Rats Rats, Wistar Rodents Rutin Rutin - pharmacology Rutin - therapeutic use Serum levels Sexual behavior Sexual Behavior, Animal - drug effects Sperm Sperm Count Sperm Motility - drug effects Spermatogenesis Spermatozoa - drug effects Spermatozoa - metabolism streptozotocin Testes testicular damage Testis - drug effects Testis - metabolism Testosterone Testosterone - blood |
| title | Effect of rutin on diabetic‐induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats |
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