Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity
Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its growth-inhibitory activity in both plant and mammalian cells. Ophiobolin A induced cell death in Nicotiana tabacum L. cv. Bright Yellow 2 (TBY-2) cells...
Gespeichert in:
| Veröffentlicht in: | International journal of oncology 2013-08, Vol.43 (2), p.575-585 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 585 |
|---|---|
| container_issue | 2 |
| container_start_page | 575 |
| container_title | International journal of oncology |
| container_volume | 43 |
| creator | BURY, MARINA NOVO-UZAL, ESTHER ANDOLFI, ANNA CIMINI, SARA WAUTHOZ, NATHALIE HEFFETER, PETRA LALLEMAND, BENJAMIN AVOLIO, FABIANA DELPORTE, CÉDRIC CIMMINO, ALESSIO DUBOIS, JACQUES VAN ANTWERPEN, PIERRE ZONNO, MARIA CHIARA VURRO, MAURIZIO POUMAY, YVES BERGER, WALTER EVIDENTE, ANTONIO DE GARA, LAURA KISS, ROBERT LOCATO, VITTORIA |
| description | Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its growth-inhibitory activity in both plant and mammalian cells. Ophiobolin A induced cell death in Nicotiana tabacum L. cv. Bright Yellow 2 (TBY-2) cells at concentrations ≥10 μM, with the TBY-2 cells showing typical features of apoptosis-like cell death. At a concentration of 5 μM, ophiobolin A did not affect plant cell viability but prevented cell proliferation. When tested on eight cancer cell lines, concentrations |
| doi_str_mv | 10.3892/ijo.2013.1979 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1932942844</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1932942844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-8706e62c4e236fa8113e4e642248a713e5022ad2e367b0afdc2bd49208d8c0403</originalsourceid><addsrcrecordid>eNpFkc1u1DAURi0EoqWwZIsssWBTD_a1k9jLqqKAVKkbWEdO7Ew8SuxgOy15KZ4RT6cUyfLP1fG50v0Qes_ojksFn90h7IAyvmOqUS_QOWsUIyCAvyx3yhSpBVdn6E1KB0qhqih7jc6AN5UAJc_Rn7tldKELk_P46hJrnGzKNpa1WB-cwcPq93rCy7jlkMNv5y-xcWmZ9Jbw6Pajjbh8vXc5BryP4SGPxPnRdS6HuGE7DLbP6YjMep715LTHeSxbqRSJz7i305Sw9ua_91F4H0oxu7zOIWLdZ1d6bG_Rq0FPyb57Oi_Qz5svP66_kdu7r9-vr25JLyqZiWxobWvohQVeD1oyxq2wtQAQUjflUVEAbcDyuumoHkwPnREKqDSyp4LyC_Tx5F1i-LWWkbSHsEZfWrZMcVACpBCFIieqjyGlaId2iW7WcWsZbY_ptCWd9phOe0yn8B-erGs3W_NM_4ujAJ9OQFrKQJwJ6ZkpJiI4oUBo1VT8LzvMm8o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932942844</pqid></control><display><type>article</type><title>Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>BURY, MARINA ; NOVO-UZAL, ESTHER ; ANDOLFI, ANNA ; CIMINI, SARA ; WAUTHOZ, NATHALIE ; HEFFETER, PETRA ; LALLEMAND, BENJAMIN ; AVOLIO, FABIANA ; DELPORTE, CÉDRIC ; CIMMINO, ALESSIO ; DUBOIS, JACQUES ; VAN ANTWERPEN, PIERRE ; ZONNO, MARIA CHIARA ; VURRO, MAURIZIO ; POUMAY, YVES ; BERGER, WALTER ; EVIDENTE, ANTONIO ; DE GARA, LAURA ; KISS, ROBERT ; LOCATO, VITTORIA</creator><creatorcontrib>BURY, MARINA ; NOVO-UZAL, ESTHER ; ANDOLFI, ANNA ; CIMINI, SARA ; WAUTHOZ, NATHALIE ; HEFFETER, PETRA ; LALLEMAND, BENJAMIN ; AVOLIO, FABIANA ; DELPORTE, CÉDRIC ; CIMMINO, ALESSIO ; DUBOIS, JACQUES ; VAN ANTWERPEN, PIERRE ; ZONNO, MARIA CHIARA ; VURRO, MAURIZIO ; POUMAY, YVES ; BERGER, WALTER ; EVIDENTE, ANTONIO ; DE GARA, LAURA ; KISS, ROBERT ; LOCATO, VITTORIA</creatorcontrib><description>Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its growth-inhibitory activity in both plant and mammalian cells. Ophiobolin A induced cell death in Nicotiana tabacum L. cv. Bright Yellow 2 (TBY-2) cells at concentrations ≥10 μM, with the TBY-2 cells showing typical features of apoptosis-like cell death. At a concentration of 5 μM, ophiobolin A did not affect plant cell viability but prevented cell proliferation. When tested on eight cancer cell lines, concentrations <1 μM of ophiobolin A inhibited growth by 50% after 3 days of culture irrespective of their multidrug resistance (MDR) phenotypes and their resistance levels to pro-apoptotic stimuli. It is, thus, unlikely that ophiobolin A exerts these in vitro growth-inhibitory effects in cancer cells by activating pro-apoptotic processes. Highly proliferative human keratinocytes appeared more sensitive to the growth-inhibitory effects of ophiobolin A than slowly proliferating ones. Ophiobolin A also displayed significant antitumor activity at the level of mouse survival when assayed at 10 mg/kg in the B16F10 mouse melanoma model with lung pseudometastases. Ophiobolin A could, thus, represent a novel scaffold to combat cancer types that display various levels of resistance to pro-apoptotic stimuli and/or various MDR phenotypes.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2013.1979</identifier><identifier>PMID: 23754298</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Cancer ; Cell culture ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; cytotoxicity ; Drug Resistance, Neoplasm ; Epidemics ; Female ; Fungi ; Humans ; Hydrogen Peroxide - metabolism ; Hypotheses ; in vivo antitumor activity ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; mammalian cells ; Melanoma ; Metabolites ; Mice ; Neoplasms - drug therapy ; Nicotiana - cytology ; ophiobolin A ; plant cells ; Plant Cells - drug effects ; Sesterterpenes - pharmacology ; Tobacco</subject><ispartof>International journal of oncology, 2013-08, Vol.43 (2), p.575-585</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-8706e62c4e236fa8113e4e642248a713e5022ad2e367b0afdc2bd49208d8c0403</citedby><cites>FETCH-LOGICAL-c458t-8706e62c4e236fa8113e4e642248a713e5022ad2e367b0afdc2bd49208d8c0403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,5569,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23754298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BURY, MARINA</creatorcontrib><creatorcontrib>NOVO-UZAL, ESTHER</creatorcontrib><creatorcontrib>ANDOLFI, ANNA</creatorcontrib><creatorcontrib>CIMINI, SARA</creatorcontrib><creatorcontrib>WAUTHOZ, NATHALIE</creatorcontrib><creatorcontrib>HEFFETER, PETRA</creatorcontrib><creatorcontrib>LALLEMAND, BENJAMIN</creatorcontrib><creatorcontrib>AVOLIO, FABIANA</creatorcontrib><creatorcontrib>DELPORTE, CÉDRIC</creatorcontrib><creatorcontrib>CIMMINO, ALESSIO</creatorcontrib><creatorcontrib>DUBOIS, JACQUES</creatorcontrib><creatorcontrib>VAN ANTWERPEN, PIERRE</creatorcontrib><creatorcontrib>ZONNO, MARIA CHIARA</creatorcontrib><creatorcontrib>VURRO, MAURIZIO</creatorcontrib><creatorcontrib>POUMAY, YVES</creatorcontrib><creatorcontrib>BERGER, WALTER</creatorcontrib><creatorcontrib>EVIDENTE, ANTONIO</creatorcontrib><creatorcontrib>DE GARA, LAURA</creatorcontrib><creatorcontrib>KISS, ROBERT</creatorcontrib><creatorcontrib>LOCATO, VITTORIA</creatorcontrib><title>Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its growth-inhibitory activity in both plant and mammalian cells. Ophiobolin A induced cell death in Nicotiana tabacum L. cv. Bright Yellow 2 (TBY-2) cells at concentrations ≥10 μM, with the TBY-2 cells showing typical features of apoptosis-like cell death. At a concentration of 5 μM, ophiobolin A did not affect plant cell viability but prevented cell proliferation. When tested on eight cancer cell lines, concentrations <1 μM of ophiobolin A inhibited growth by 50% after 3 days of culture irrespective of their multidrug resistance (MDR) phenotypes and their resistance levels to pro-apoptotic stimuli. It is, thus, unlikely that ophiobolin A exerts these in vitro growth-inhibitory effects in cancer cells by activating pro-apoptotic processes. Highly proliferative human keratinocytes appeared more sensitive to the growth-inhibitory effects of ophiobolin A than slowly proliferating ones. Ophiobolin A also displayed significant antitumor activity at the level of mouse survival when assayed at 10 mg/kg in the B16F10 mouse melanoma model with lung pseudometastases. Ophiobolin A could, thus, represent a novel scaffold to combat cancer types that display various levels of resistance to pro-apoptotic stimuli and/or various MDR phenotypes.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cancer</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>cytotoxicity</subject><subject>Drug Resistance, Neoplasm</subject><subject>Epidemics</subject><subject>Female</subject><subject>Fungi</subject><subject>Humans</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hypotheses</subject><subject>in vivo antitumor activity</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - metabolism</subject><subject>mammalian cells</subject><subject>Melanoma</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Neoplasms - drug therapy</subject><subject>Nicotiana - cytology</subject><subject>ophiobolin A</subject><subject>plant cells</subject><subject>Plant Cells - drug effects</subject><subject>Sesterterpenes - pharmacology</subject><subject>Tobacco</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkc1u1DAURi0EoqWwZIsssWBTD_a1k9jLqqKAVKkbWEdO7Ew8SuxgOy15KZ4RT6cUyfLP1fG50v0Qes_ojksFn90h7IAyvmOqUS_QOWsUIyCAvyx3yhSpBVdn6E1KB0qhqih7jc6AN5UAJc_Rn7tldKELk_P46hJrnGzKNpa1WB-cwcPq93rCy7jlkMNv5y-xcWmZ9Jbw6Pajjbh8vXc5BryP4SGPxPnRdS6HuGE7DLbP6YjMep715LTHeSxbqRSJz7i305Sw9ua_91F4H0oxu7zOIWLdZ1d6bG_Rq0FPyb57Oi_Qz5svP66_kdu7r9-vr25JLyqZiWxobWvohQVeD1oyxq2wtQAQUjflUVEAbcDyuumoHkwPnREKqDSyp4LyC_Tx5F1i-LWWkbSHsEZfWrZMcVACpBCFIieqjyGlaId2iW7WcWsZbY_ptCWd9phOe0yn8B-erGs3W_NM_4ujAJ9OQFrKQJwJ6ZkpJiI4oUBo1VT8LzvMm8o</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>BURY, MARINA</creator><creator>NOVO-UZAL, ESTHER</creator><creator>ANDOLFI, ANNA</creator><creator>CIMINI, SARA</creator><creator>WAUTHOZ, NATHALIE</creator><creator>HEFFETER, PETRA</creator><creator>LALLEMAND, BENJAMIN</creator><creator>AVOLIO, FABIANA</creator><creator>DELPORTE, CÉDRIC</creator><creator>CIMMINO, ALESSIO</creator><creator>DUBOIS, JACQUES</creator><creator>VAN ANTWERPEN, PIERRE</creator><creator>ZONNO, MARIA CHIARA</creator><creator>VURRO, MAURIZIO</creator><creator>POUMAY, YVES</creator><creator>BERGER, WALTER</creator><creator>EVIDENTE, ANTONIO</creator><creator>DE GARA, LAURA</creator><creator>KISS, ROBERT</creator><creator>LOCATO, VITTORIA</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130801</creationdate><title>Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity</title><author>BURY, MARINA ; NOVO-UZAL, ESTHER ; ANDOLFI, ANNA ; CIMINI, SARA ; WAUTHOZ, NATHALIE ; HEFFETER, PETRA ; LALLEMAND, BENJAMIN ; AVOLIO, FABIANA ; DELPORTE, CÉDRIC ; CIMMINO, ALESSIO ; DUBOIS, JACQUES ; VAN ANTWERPEN, PIERRE ; ZONNO, MARIA CHIARA ; VURRO, MAURIZIO ; POUMAY, YVES ; BERGER, WALTER ; EVIDENTE, ANTONIO ; DE GARA, LAURA ; KISS, ROBERT ; LOCATO, VITTORIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-8706e62c4e236fa8113e4e642248a713e5022ad2e367b0afdc2bd49208d8c0403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Cancer</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>cytotoxicity</topic><topic>Drug Resistance, Neoplasm</topic><topic>Epidemics</topic><topic>Female</topic><topic>Fungi</topic><topic>Humans</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hypotheses</topic><topic>in vivo antitumor activity</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - metabolism</topic><topic>mammalian cells</topic><topic>Melanoma</topic><topic>Metabolites</topic><topic>Mice</topic><topic>Neoplasms - drug therapy</topic><topic>Nicotiana - cytology</topic><topic>ophiobolin A</topic><topic>plant cells</topic><topic>Plant Cells - drug effects</topic><topic>Sesterterpenes - pharmacology</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURY, MARINA</creatorcontrib><creatorcontrib>NOVO-UZAL, ESTHER</creatorcontrib><creatorcontrib>ANDOLFI, ANNA</creatorcontrib><creatorcontrib>CIMINI, SARA</creatorcontrib><creatorcontrib>WAUTHOZ, NATHALIE</creatorcontrib><creatorcontrib>HEFFETER, PETRA</creatorcontrib><creatorcontrib>LALLEMAND, BENJAMIN</creatorcontrib><creatorcontrib>AVOLIO, FABIANA</creatorcontrib><creatorcontrib>DELPORTE, CÉDRIC</creatorcontrib><creatorcontrib>CIMMINO, ALESSIO</creatorcontrib><creatorcontrib>DUBOIS, JACQUES</creatorcontrib><creatorcontrib>VAN ANTWERPEN, PIERRE</creatorcontrib><creatorcontrib>ZONNO, MARIA CHIARA</creatorcontrib><creatorcontrib>VURRO, MAURIZIO</creatorcontrib><creatorcontrib>POUMAY, YVES</creatorcontrib><creatorcontrib>BERGER, WALTER</creatorcontrib><creatorcontrib>EVIDENTE, ANTONIO</creatorcontrib><creatorcontrib>DE GARA, LAURA</creatorcontrib><creatorcontrib>KISS, ROBERT</creatorcontrib><creatorcontrib>LOCATO, VITTORIA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURY, MARINA</au><au>NOVO-UZAL, ESTHER</au><au>ANDOLFI, ANNA</au><au>CIMINI, SARA</au><au>WAUTHOZ, NATHALIE</au><au>HEFFETER, PETRA</au><au>LALLEMAND, BENJAMIN</au><au>AVOLIO, FABIANA</au><au>DELPORTE, CÉDRIC</au><au>CIMMINO, ALESSIO</au><au>DUBOIS, JACQUES</au><au>VAN ANTWERPEN, PIERRE</au><au>ZONNO, MARIA CHIARA</au><au>VURRO, MAURIZIO</au><au>POUMAY, YVES</au><au>BERGER, WALTER</au><au>EVIDENTE, ANTONIO</au><au>DE GARA, LAURA</au><au>KISS, ROBERT</au><au>LOCATO, VITTORIA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>43</volume><issue>2</issue><spage>575</spage><epage>585</epage><pages>575-585</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Ophiobolin A, a sesterterpenoid produced by plant pathogenic fungi, was purified from the culture extract of Drechslera gigantea and tested for its growth-inhibitory activity in both plant and mammalian cells. Ophiobolin A induced cell death in Nicotiana tabacum L. cv. Bright Yellow 2 (TBY-2) cells at concentrations ≥10 μM, with the TBY-2 cells showing typical features of apoptosis-like cell death. At a concentration of 5 μM, ophiobolin A did not affect plant cell viability but prevented cell proliferation. When tested on eight cancer cell lines, concentrations <1 μM of ophiobolin A inhibited growth by 50% after 3 days of culture irrespective of their multidrug resistance (MDR) phenotypes and their resistance levels to pro-apoptotic stimuli. It is, thus, unlikely that ophiobolin A exerts these in vitro growth-inhibitory effects in cancer cells by activating pro-apoptotic processes. Highly proliferative human keratinocytes appeared more sensitive to the growth-inhibitory effects of ophiobolin A than slowly proliferating ones. Ophiobolin A also displayed significant antitumor activity at the level of mouse survival when assayed at 10 mg/kg in the B16F10 mouse melanoma model with lung pseudometastases. Ophiobolin A could, thus, represent a novel scaffold to combat cancer types that display various levels of resistance to pro-apoptotic stimuli and/or various MDR phenotypes.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23754298</pmid><doi>10.3892/ijo.2013.1979</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1019-6439 |
| ispartof | International journal of oncology, 2013-08, Vol.43 (2), p.575-585 |
| issn | 1019-6439 1791-2423 |
| language | eng |
| recordid | cdi_proquest_journals_1932942844 |
| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cancer Cell culture Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects cytotoxicity Drug Resistance, Neoplasm Epidemics Female Fungi Humans Hydrogen Peroxide - metabolism Hypotheses in vivo antitumor activity Keratinocytes - drug effects Keratinocytes - metabolism mammalian cells Melanoma Metabolites Mice Neoplasms - drug therapy Nicotiana - cytology ophiobolin A plant cells Plant Cells - drug effects Sesterterpenes - pharmacology Tobacco |
| title | Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T23%3A10%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ophiobolin%20A,%20a%20sesterterpenoid%20fungal%20phytotoxin,%20displays%20higher%20in%20vitro%20growth-inhibitory%20effects%20in%20mammalian%20than%20in%20plant%20cells%20and%20displays%20in%20vivo%20antitumor%20activity&rft.jtitle=International%20journal%20of%20oncology&rft.au=BURY,%20MARINA&rft.date=2013-08-01&rft.volume=43&rft.issue=2&rft.spage=575&rft.epage=585&rft.pages=575-585&rft.issn=1019-6439&rft.eissn=1791-2423&rft_id=info:doi/10.3892/ijo.2013.1979&rft_dat=%3Cproquest_cross%3E1932942844%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932942844&rft_id=info:pmid/23754298&rfr_iscdi=true |