The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro
Endometrial carcinoma is the most common gynaecological malignancy. Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are t...
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| Veröffentlicht in: | International journal of oncology 2014-07, Vol.45 (1), p.373-382 |
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| creator | HAHNE, JENS C MEYER, SUSANNE R DIETL, JOHANNES HONIG, ARND |
| description | Endometrial carcinoma is the most common gynaecological malignancy. Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three endometrial cancer cell lines, Ishikawa, Hec-1A and AN3-CA (derived from endometrial cancers grade I, II and III, respectively), were used to determine the effect of the fungi extracts on endometrial cancer cell function and to analyze the molecular mechanism. All fungi extracts had an inhibitory effect on cell viability and proliferation most probably exerted through induction of autophagy. Our data suggest that these fungi extracts may be used as adjuvants in endometrial tumour therapy. |
| doi_str_mv | 10.3892/ijo.2014.2414 |
| format | Article |
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Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three endometrial cancer cell lines, Ishikawa, Hec-1A and AN3-CA (derived from endometrial cancers grade I, II and III, respectively), were used to determine the effect of the fungi extracts on endometrial cancer cell function and to analyze the molecular mechanism. All fungi extracts had an inhibitory effect on cell viability and proliferation most probably exerted through induction of autophagy. Our data suggest that these fungi extracts may be used as adjuvants in endometrial tumour therapy.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2014.2414</identifier><identifier>PMID: 24805296</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Agaricus ; Agaricus - chemistry ; Agaricus Blazi Murill ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacology ; Apoptosis ; autophagic cell death ; Autophagy ; Autophagy - drug effects ; Cancer therapies ; Care and treatment ; Cell cycle ; Cell death ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chemotherapy, Adjuvant ; Chinese medicine ; Cordyceps ; Cordyceps - chemistry ; Cordyceps Sinensis ; Cytotoxicity ; Dose-Response Relationship, Drug ; Drugs ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - pharmacology ; Endometrial cancer ; Endometrial Neoplasms - pathology ; Experiments ; Female ; Fungi ; Ganoderma lucidum ; Health aspects ; Humans ; Immune system ; Materia medica, Vegetable ; Mushrooms ; Penicillin ; Plant extracts ; Reishi ; Reishi - chemistry ; Signal Transduction - drug effects ; Sterols ; Studies</subject><ispartof>International journal of oncology, 2014-07, Vol.45 (1), p.373-382</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-5276882e889726080022124dabda60c973eeb46b9ade0d511f3d2423adba0c303</citedby><cites>FETCH-LOGICAL-c490t-5276882e889726080022124dabda60c973eeb46b9ade0d511f3d2423adba0c303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,5569,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24805296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAHNE, JENS C</creatorcontrib><creatorcontrib>MEYER, SUSANNE R</creatorcontrib><creatorcontrib>DIETL, JOHANNES</creatorcontrib><creatorcontrib>HONIG, ARND</creatorcontrib><title>The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Endometrial carcinoma is the most common gynaecological malignancy. Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three endometrial cancer cell lines, Ishikawa, Hec-1A and AN3-CA (derived from endometrial cancers grade I, II and III, respectively), were used to determine the effect of the fungi extracts on endometrial cancer cell function and to analyze the molecular mechanism. All fungi extracts had an inhibitory effect on cell viability and proliferation most probably exerted through induction of autophagy. Our data suggest that these fungi extracts may be used as adjuvants in endometrial tumour therapy.</description><subject>Agaricus</subject><subject>Agaricus - chemistry</subject><subject>Agaricus Blazi Murill</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>autophagic cell death</subject><subject>Autophagy</subject><subject>Autophagy - drug effects</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chemotherapy, Adjuvant</subject><subject>Chinese medicine</subject><subject>Cordyceps</subject><subject>Cordyceps - chemistry</subject><subject>Cordyceps Sinensis</subject><subject>Cytotoxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Experiments</subject><subject>Female</subject><subject>Fungi</subject><subject>Ganoderma lucidum</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune system</subject><subject>Materia medica, Vegetable</subject><subject>Mushrooms</subject><subject>Penicillin</subject><subject>Plant extracts</subject><subject>Reishi</subject><subject>Reishi - chemistry</subject><subject>Signal Transduction - drug effects</subject><subject>Sterols</subject><subject>Studies</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1v1DAQhiMEoqVw5IosIcEpW3_FiY_LqhSkIi7lbDn2pOtVYi92XLX8Cn5yHW1ZqIR8sDV6Zqx3nqp6S_CKdZKeu11YUUz4inLCn1WnpJWkppyy5-WNiawFZ_KkepXSDmPaNJi8rE4o73BDpTitfl9vAcEwgJlRGNAmRHtvYJ8Q3M1Rl6L2Fmk0ubs5R1iQS-2DhThpNGbjbJ7O1zc6OpMT-jTqXw59y9GN43FA8GibJ-0ReBsmmKPTIzLaG4jIQAFH5yEh59Gtm2N4Xb0Y9JjgzeN9Vv34fHG9-VJffb_8ullf1YZLPNcNbUXXUeg62VKBu5KNEsqt7q0W2MiWAfRc9FJbwLYhZGB22Yq2vcaGYXZWvT_M3cfwM0Oa1S7k6MuXikhGu7IgIf9SN3oE5fwQllCTS0atORVUcsFEoVb_ocqxMDkTPAyu1J80fPinYQt6nLcpjHl2waenYH0ATQwpRRjUPrpJx3tFsFr8q-JfLf7V4r_w7x5T5X4Ce6T_CC_AxwOQ9sWssyEdmTKp5k2NSY1Zy9gD67q3IQ</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>HAHNE, JENS C</creator><creator>MEYER, SUSANNE R</creator><creator>DIETL, JOHANNES</creator><creator>HONIG, ARND</creator><general>D.A. 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Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis. Cordyceps Sinensis, Ganoderma lucidum and Agaricus Blazi Murill are three fungi widely used in traditional Chinese medicine, and effects as adjuvants in tumour therapy have been demonstrated. However, the function and effects of these fungi in regard to endometrial cancer are not known. Three endometrial cancer cell lines, Ishikawa, Hec-1A and AN3-CA (derived from endometrial cancers grade I, II and III, respectively), were used to determine the effect of the fungi extracts on endometrial cancer cell function and to analyze the molecular mechanism. All fungi extracts had an inhibitory effect on cell viability and proliferation most probably exerted through induction of autophagy. Our data suggest that these fungi extracts may be used as adjuvants in endometrial tumour therapy.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24805296</pmid><doi>10.3892/ijo.2014.2414</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of oncology, 2014-07, Vol.45 (1), p.373-382 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Agaricus Agaricus - chemistry Agaricus Blazi Murill Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis autophagic cell death Autophagy Autophagy - drug effects Cancer therapies Care and treatment Cell cycle Cell death Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy, Adjuvant Chinese medicine Cordyceps Cordyceps - chemistry Cordyceps Sinensis Cytotoxicity Dose-Response Relationship, Drug Drugs Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - pharmacology Endometrial cancer Endometrial Neoplasms - pathology Experiments Female Fungi Ganoderma lucidum Health aspects Humans Immune system Materia medica, Vegetable Mushrooms Penicillin Plant extracts Reishi Reishi - chemistry Signal Transduction - drug effects Sterols Studies |
| title | The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro |
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