A novel trifluoromethyl benzopyran induces G1 cell cycle arrest and apoptosis in HeLa human cervical carcinoma cells

In the present study, a biologically active 4-(trifluoromethyl)phenyl piperazin moiety was linked to a 2,2-dimethyl-2H-benzopyran template to generate (3R,4S)-2,2-dimethyl-6-nitro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl) chroman-3-ol (C110g), and the cellular and molecular mechanisms by which...

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Veröffentlicht in:	International journal of oncology 2013-08, Vol.43 (2), p.469-476
Hauptverfasser:	ZHANG, XIN, HWANG, JIYOUNG, JIA, XIAN, SHIN, DONG-SOO, YOU, SONG, KIM, DONG-KYOO
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Benzopyrans - pharmacology Caspase 3 - metabolism Caspase 9 - metabolism Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cervical cancer Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cytochrome Cytochromes c - secretion Cytotoxicity Deoxyribonucleic acid DNA DNA damage Enzyme Activation Female G1 cell cycle arrest G1 Phase Cell Cycle Checkpoints - drug effects HeLa Cells Humans Investigations Kinases Laboratories Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Natural products Potassium Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species trifluoromethyl benzopyran Tumor Suppressor Protein p53 - metabolism Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism
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