A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells

Colorectal cancer (CRC) is one of the most common malignant diseases and frequent cause of cancer deaths in the world. In spite of the significant advances in conventional therapeutic approaches to CRC, most patients ultimately die of their disease. There is a need to develop novel preventive approa...

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Veröffentlicht in:	International journal of oncology 2014-01, Vol.44 (1), p.256-264
Hauptverfasser:	KIM, MI KYEONG, KANG, YONG JUNG, KIM, DONG HWAN, HOSSAIN, MOHAMMAD AKBAR, JANG, JUNG YOON, LEE, SUN HWA, YOON, JEONG-HYUN, CHUN, PUSOON, MOON, HYUNG RYONG, KIM, HYUNG SIK, CHUNG, HAE YOUNG, KIM, NAM DEUK
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Cancer therapies Care and treatment Cell cycle Cell Cycle Checkpoints - drug effects Cell growth Cell Proliferation - drug effects Colon cancer colon cancer cells Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Control Cyclin B1 - biosynthesis Cytotoxicity Deoxyribonucleic acid Development and progression DNA Flow cytometry G2 Phase Cell Cycle Checkpoints - drug effects Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects HCT116 Cells Humans hydroxamic acid derivative Hydroxamic Acids - administration & dosage Inflammation NF-kappa B - genetics NF-kappa B - metabolism NF-κB Phenyl Ethers - administration & dosage Pimelic Acids - administration & dosage Prevention Proteins rho GTP-Binding Proteins - biosynthesis Studies
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