Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E

Intensive protein synthesis is a unique and differential trait of the multiple myeloma (MM) cells. Previously we showed that tetraspanin overexpression in MM cell lines attenuated mTOR and PI3K cascades, induced protein synthesis, activated unfolded protein response (UPR), and caused autophagic deat...

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Veröffentlicht in:	International journal of oncology 2015-02, Vol.46 (2), p.860-870
Hauptverfasser:	ZISMANOV, VICTORIA, ATTAR-SCHNEIDER, OSHRAT, LISHNER, MICHAEL, AIZENFELD, RACHEL HEFFEZ, MATALON, SHELLY TARTAKOVER, DRUCKER, LIAT
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Antibiotics Antiviral agents Antiviral drugs Autophagy - drug effects Bone marrow CD81N1 CD82N1 Cell Line, Tumor Cyclin D1 - biosynthesis Drug therapy eIF4E Eukaryotic Initiation Factor-4E - antagonists & inhibitors Eukaryotic Initiation Factor-4E - genetics Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genetic translation Health aspects Humans Inhibitor drugs Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Protein biosynthesis Protein synthesis Proteins Proto-Oncogene Proteins c-myc - biosynthesis ribavirin Ribavirin - administration & dosage RNA, Small Interfering tetraspanins Tetraspanins - administration & dosage Tetraspanins - biosynthesis TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Unfolded Protein Response - genetics velcade
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