The importance of mitochondrial folate enzymes in human colorectal cancer

Folate plays a pivotal role in the one-carbon metabolism needed for methylation reactions, nucleotide synthesis, and DNA repair. Although folate metabolism was recently shown to be associated with carcinogenesis in some solid tumors, the importance of folate metabolism in colorectal cancer remains u...

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Veröffentlicht in:	Oncology reports 2017-01, Vol.37 (1), p.417-425
Hauptverfasser:	Miyo, Masaaki, Konno, Masamitsu, Colvin, Hugh, Nishida, Naohiro, Koseki, Jun, Kawamoto, Koichi, Tsunekuni, Kenta, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - enzymology Adenocarcinoma - metabolism Adenocarcinoma - mortality Adult Aged Aged, 80 and over aldehyde dehydrogenase 1 family member L2 Antigens Biomarkers, Tumor - metabolism Breast cancer Carcinogenesis - metabolism Care and treatment Case-Control Studies Cell metabolism Classification Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - enzymology Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Dehydrogenases Deoxyribonucleic acid Development and progression Dihydrofolate reductase DNA DNA methylation Enzymes Female folate Folic acid Folic Acid - metabolism Gender Gene expression Genetic aspects Genomes Genomics Health aspects Humans Lymphatic system Male Medical prognosis Metabolic Networks and Pathways - physiology Metabolism Metabolites Metastasis methylenetetrahydrofolate dehydrogenase Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism Methylenetetrahydrofolate Reductase (NADPH2) - metabolism Middle Aged Mitochondria - enzymology Mitochondria - metabolism Multivariate analysis Patients Prognosis serine hydroxymethyl transferase Studies Surgery Survival Analysis Tumors Vitamin B
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