TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways

Breast cancer is the second leading cause of cancer-related deaths in female patients, and the main reasons are late diagnosis, limited therapeutic options and metastasis. Therefore, development of molecular therapeutic targets for breast cancer to suppress tumorigenesis, growth and metastasis may i...

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Veröffentlicht in:	Oncology reports 2016-12, Vol.36 (6), p.3311-3316
Hauptverfasser:	Zhang, Zhenhua, Liu, Li, Liu, Chunliang, Cao, Shousong, Zhu, Yizhun, Mei, Qibing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AKT Animals Apoptosis Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Carcinogenesis - metabolism Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - secondary Care and treatment Cell growth Cell Line, Tumor Cell Proliferation Cellular signal transduction Development and progression Female Gene expression Genetic aspects Health aspects HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - physiology Liver cancer Lung cancer MAP Kinase Signaling System Medical prognosis Metabolism Metastasis Mice, Nude Middle Aged Neoplasm Invasiveness Neoplasm Transplantation p38 Phosphatidylinositol 3-Kinases - metabolism Plasmids Proteins Proto-Oncogene Proteins c-akt - metabolism Rodents Studies TIPE2 Tumor Burden Tumor proteins Tumorigenesis
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