Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway

Sulforaphane is recognized as a safe antitumor agent derived from various cruciferous vegetables, including broccoli. It has been demonstrated that sulforaphase is a potent antitumor agent in diverse cancers. However, its effect on hepatocellular carcinoma remains largely unknown. Here, we show that...

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Veröffentlicht in:	Oncology reports 2016-05, Vol.35 (5), p.2977-2983
Hauptverfasser:	WU, JINSHENG, HAN, JINGLI, HOU, BENXIN, DENG, CHENGWEI, WU, HUANLIANG, SHEN, LIANGFANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Bladder cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell Movement Cell Shape - drug effects Colorectal cancer Development and progression epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Female G1 Phase Cell Cycle Checkpoints Gene expression Genetic aspects Growth models Health aspects Hep G2 Cells hepatocellular carcinoma Hepatoma Humans Inhibitory Concentration 50 Isothiocyanates - pharmacology Leukemia Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Medical prognosis Metastasis Mice, Inbred BALB C Mice, Nude Microscopy Morphology Neoplasm Invasiveness Properties Reactive oxygen species Reactive Oxygen Species - metabolism Studies sulforaphane Thiocyanates Thyroid cancer Transforming Growth Factor beta - physiology Transforming growth factors Xenograft Model Antitumor Assays
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