Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma

Worldwide, the highest prevalence of esophageal cancer (EC) occurs in Northern China. High-density SNP arrays allow identification of identity-by-descent (IBD) segments in genomic DNAs representative of shared common ancestral regions. We utilized IBD approaches to map susceptibility loci associated...

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Veröffentlicht in:	Oncology reports 2014-08, Vol.32 (2), p.860-870
Hauptverfasser:	KO, JOSEPHINE MY, ZHANG, PENG, LAW, SIMON, FAN, YANHUI, SONG, YOU-QIANG, ZHAO, XUE KE, WONG, ELIBE H.W, TANG, SA, SONG, XIN, LUNG, MARIA LI, WANG, LI DONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis Asian Continental Ancestry Group - genetics Carcinoma, Squamous Cell - ethnology Carcinoma, Squamous Cell - genetics Care and treatment China - epidemiology Chinese Chromosomes, Human Consanguinity Datasets Deoxyribonucleic acid Diagnosis Disease susceptibility DNA Esophageal cancer Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics Esophageal Squamous Cell Carcinoma Family medical history Female Genetic aspects Genetic Predisposition to Disease genetic susceptibility Genome-Wide Association Study Genotype Genotype & phenotype Humans IBD inherited ESCC Male Middle Aged Oligonucleotide Array Sequence Analysis Physiological aspects Polymorphism, Single Nucleotide Quality control Single nucleotide polymorphisms SNP array Software Squamous cell carcinoma Statistical analysis Studies
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