E2F1 acts as a negative feedback regulator of c-Myc-induced hTERT transcription during tumorigenesis

Since induction of hTERT expression and subsequent telomerase activation play a critical role in the multistep process of tumorigenesis, a better understanding of hTERT regulation may provide not only a rationale for the molecular basis of cancer progression but also a path to the development of can...

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Veröffentlicht in:	Oncology reports 2014-09, Vol.32 (3), p.1273-1280
Hauptverfasser:	ZHANG, YAFEI, ZHANG, ANRAN, SHEN, CAIFEI, ZHANG, BICHENG, RAO, ZHIGUO, WANG, RONGQUAN, YANG, SHIMING, NING, SHOUBIN, MAO, GAOPING, FANG, DIANCHUN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Apoptosis c-Myc Cancer Cell growth Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells, Cultured E2F1 E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Embryo, Mammalian - cytology Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation, Neoplastic Genetic aspects Genetic transcription Health aspects hTERT Humans MicroRNAs - genetics miR-17-92 cluster Models, Biological negative feedback regulation Oncology, Experimental Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rodents Studies Telomerase Telomerase - genetics Telomerase - metabolism Transcription factors Tumorigenesis
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