Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells

DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and metastasis. In recent years, several inhibitors of DNA methyltransferases (DNMTis) have been developed and evaluated in pre-clinical models an...

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Veröffentlicht in:	Oncology reports 2013-03, Vol.29 (3), p.1189-1195
Hauptverfasser:	GRAVINA, GIOVANNI LUCA, RANIERI, GUIDO, MUZI, PAOLA, MARAMPON, FRANCESCO, MANCINI, ANDREA, DI PASQUALE, BORIS, DI CLEMENTE, LUIGI, DOLO, VINCENZA, D'ALESSANDRO, ANNA MARIA, FESTUCCIA, CLAUDIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Antimetabolites, Antineoplastic - pharmacology Azacitidine - pharmacology Cancer therapies Carcinogenesis - metabolism Cell Line, Tumor Clinical trials Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA methyltransferase DNA Methyltransferase 3A DNA Methyltransferase 3B Endocrine therapy Enzymes Epigenetics epigenome Epithelial Cells - enzymology Gene Expression - drug effects Genes Glutathione S-Transferase pi - genetics Glutathione S-Transferase pi - metabolism Humans Male Metastasis Phenotype Prostate - enzymology Prostate cancer Prostatic Hyperplasia - enzymology Prostatic Neoplasms - enzymology Tumors
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