Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma

Colorectal cancer is one of the leading causes of cancer-related death worldwide. Molecular biomarkers could help to predict patient outcome and to identify patients who benefit from adjuvant therapy. Pontin and Reptin are ATPases which are involved in transcriptional regulation, DNA damage repair a...

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Veröffentlicht in:	Oncology reports 2012-11, Vol.28 (5), p.1619-1624
Hauptverfasser:	LAUSCHER, JOHANNES C, ELEZKURTAJ, SEFER, DULLAT, SONJA, LIPKA, SYBILLE, GRÖNE, JÖRN, BUHR, HEINZ J, HUBER, OTMAR, KRUSCHEWSKI, MARTIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality adjuvant therapy Adult Aged Aged, 80 and over Apoptosis ATPases Associated with Diverse Cellular Activities Biological and medical sciences Biomarkers, Tumor - metabolism Cancer therapies Carrier Proteins - metabolism Cell cycle Cell growth Chemotherapy Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Deoxyribonucleic acid Disease-Free Survival DNA DNA damage DNA Helicases - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen Gene expression Humans Ki-67 Antigen - metabolism Male Medical prognosis Medical sciences Middle Aged Multivariate analysis Mutation Neoplasm Recurrence, Local Pontin prognosis Proteins Proto-Oncogene Proteins c-myc - metabolism Reptin Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome Tumors
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