High susceptibility of heterozygous (+/fa) lean Zucker rats to 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis

Susceptibility to 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis was investigated in lean Zucker (+/fa) rats carrying one mutated leptin receptor gene and wild-type controls (+/+). Rats with both genotypes were given a single DMBA administration and divided into two groups, one...

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Veröffentlicht in:	Oncology reports 2013-05, Vol.29 (5), p.1914-1922
Hauptverfasser:	IMAI, TOSHIO, CHO, YOUNG-MAN, TAKAHASHI, MAMI, KITAHASHI, TSUKASA, TAKAMI, SHIGEAKI, NISHIKAWA, AKIYOSHI, OGAWA, KUMIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	7,12-dimethylbenz(a)anthracene 9,10-Dimethyl-1,2-benzanthracene Age Animals Biochemistry Body Weight - drug effects Body Weight - genetics Breast cancer Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - pathology carcinoma Cell Differentiation - drug effects Cell Differentiation - genetics Cell growth Cholesterol Corn Oil - genetics Corn Oil - metabolism Diet Diet - methods Eating - drug effects Eating - genetics Female Genotype & phenotype Heterozygote Kinases leptin Leptin - genetics Leptin - metabolism mammary Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics Morphology Obesity Rats Rats, Zucker Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, Leptin - genetics Receptors, Leptin - metabolism Rodents Studies Survival Rate Triglycerides Tumorigenesis Tumors Zea mays Zucker rat
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