Chk1 knockdown confers radiosensitization in prostate cancer stem cells

Radioresistance is responsible for treatment failure after radiotherapy in localized prostate cancer, while prostate cancer stem cells promote radioresistance by preferential activation of the DNA damage response. Chk1 inhibition has been shown to sensitize many tumor cells to radiation. However, wh...

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Veröffentlicht in:	Oncology reports 2012-12, Vol.28 (6), p.2247-2254
Hauptverfasser:	WANG, XIAOBIN, MA, ZHIKUN, XIAO, ZHENG, LIU, HUI, DOU, ZHONGLING, FENG, XIAOSHAN, SHI, HAIJUN
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD Apoptosis Apoptosis - radiation effects Biological and medical sciences cancer stem cells Cancer therapies Caspase 2 - metabolism CDC2 Protein Kinase cdc25 Phosphatases - biosynthesis Cell cycle Cell Cycle Checkpoints - radiation effects Cell Line, Tumor Checkpoint Kinase 1 Chk1 Cyclin B - biosynthesis Cyclin-Dependent Kinases Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA repair DNA Repair - radiation effects Flow cytometry Glycoproteins Humans Hyaluronan Receptors Male Medical sciences Mitosis - radiation effects Neoplastic Stem Cells - radiation effects Nephrology. Urinary tract diseases Peptides Plasmids Prostate cancer Prostatic Neoplasms - genetics Protein Kinases - genetics Protein Kinases - metabolism Radiation therapy Radiation Tolerance - genetics RNA Interference RNA, Small Interfering Software Stem cells Tumors Tumors of the urinary system Urinary tract. Prostate gland
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