Effects of diesel exhaust particles on microRNA-21 in human bronchial epithelial cells and potential carcinogenic mechanisms

Air pollution plays a role in cancer risk, particularly in lung cancer, which is the leading cause of cancer-related mortality worldwide. Diesel exhaust particles (DEPs), a component of diesel exhaust products, is a complex mixture of particle compounds that include a large number of known and suspe...

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Veröffentlicht in:	Molecular medicine reports 2015-08, Vol.12 (2), p.2329-2335
Hauptverfasser:	ZHOU, FANG, LI, SULI, JIA, WENLIANG, LV, GANG, SONG, CHONGLIN, KANG, CHUNSHENG, ZHANG, QINGYU
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Air pollution AKT protein antisense oligonucleotide of microRNA-21 Apoptosis Apoptosis - drug effects Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Cancer therapies Carcinogenesis Carcinogens Carcinogens - toxicity Cell cycle Cell Cycle - drug effects Cell Line Cell Line, Tumor Cell Movement - drug effects Collagen - chemistry Development and progression Diesel diesel exhaust particles Diesel fuels Diesel motor exhaust gas Drug Combinations Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Fluorides Gene expression Gene Expression Regulation Genetic aspects Health aspects Humans Kinases Laboratories Laminin - chemistry lung adenocarcinoma cells Lung cancer Lung diseases MicroRNA microRNA-21 MicroRNAs MicroRNAs - agonists MicroRNAs - genetics MicroRNAs - metabolism miRNA Morphology normal human bronchial epithelial cells Outdoor air quality Particles Particulate Matter - toxicity Penicillin Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Properties Proteins Proteoglycans - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Signal transduction Signal Transduction - drug effects Studies Tumorigenesis Vehicle Emissions - toxicity
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