Protective effect of ocotillol against doxorubicin-induced acute and chronic cardiac injury

Doxorubicin (Dox) has been clinically observed to exert marked anticancer activity. However, it is severely restricted by its associated dose-dependent cardiotoxicity, which may be attenuated by decreasing the cumulative dosage via combining with a non-toxic 'sensitizer'. We previously rep...

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Veröffentlicht in:	Molecular medicine reports 2014-01, Vol.9 (1), p.360-364
Hauptverfasser:	FU, XIAOYA, KONG, LIANG, TANG, MINGTAN, ZHANG, JIANQIAO, ZHOU, XUEYING, LI, GANG, WANG, HONGBO, FU, FENGHUA
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antioxidants Antitumor activity Blood Bone marrow Cancer Cardiomyopathies - chemically induced Cardiomyopathies - drug therapy Cardiomyopathies - mortality Cardiomyopathy Cardiotoxicity Chronic Disease Creatine Creatine kinase Creatine Kinase, MB Form - blood Cytotoxicity Disease Models, Animal Doxorubicin Drug therapy Enzymes Genetic aspects Ginsenosides - chemistry Ginsenosides - therapeutic use Glutathione Glutathione - metabolism Health aspects Heart Heart diseases Kaplan-Meier Estimate Kinases Leukocyte Count Leukocytes - cytology Leukocytes - drug effects Male Malondialdehyde Malondialdehyde - metabolism Mice Myocardium - metabolism Myocardium - pathology ocotillol Oxidative stress Pharmaceutical industry Protective Agents - chemistry Protective Agents - therapeutic use Standard deviation
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