Role of Nogo-A in the regulation of hepatocellular carcinoma SMMC-7721 cell apoptosis
Nogo-A has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. However, little is known about the role of Nogo-A in hepatocellular carcinoma (HCC), the most common primary malignant tumor with a high mortality rate. This study aimed to investigate the role of...
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| Veröffentlicht in: | Molecular medicine reports 2014-05, Vol.9 (5), p.1743-1748 |
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| creator | HAO, CHUN-QIU ZHOU, YUN WANG, JIU-PING PENG, MEI-JUN XIE, YU-MEI KANG, WEN-ZHEN SUN, LI WANG, PING-ZHONG WAN, CHUN-LING HE, LIN CAI, LEI JIA, ZHANG-SHENG |
| description | Nogo-A has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. However, little is known about the role of Nogo-A in hepatocellular carcinoma (HCC), the most common primary malignant tumor with a high mortality rate. This study aimed to investigate the role of endogenous Nogo-A in human liver cancer cells. Reverse transcription polymerase chain reaction was used to detect the expression of Nogo-A in four liver cancer cell lines. A lentivirus vector was then constructed to mediate RNA interference (RNAi) targeting of Nogo-A (LV-Nogo-A-siRNA) and was confirmed to successfully suppress the expression of the Nogo-A gene in SMMC-7721 cells. Furthermore, Nogo-A was observed to be highly expressed in liver cancer cell lines. RNAi of Nogo-A using the LV-Nogo-A-siRNA construct significantly decreased Nogo-A protein expression and specifically inhibited the growth of SMMC-7721 cells. This growth inhibitory effect may be attributed to an increase in G2/M phase arrest and apoptosis in SMMC-7721 cells containing Nogo-A-siRNA. The results of this study demonstrate that Nogo-A may represent a novel therapeutic target for the treatment of liver cancer, in addition to its potent roles in neural systems. |
| doi_str_mv | 10.3892/mmr.2014.2050 |
| format | Article |
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However, little is known about the role of Nogo-A in hepatocellular carcinoma (HCC), the most common primary malignant tumor with a high mortality rate. This study aimed to investigate the role of endogenous Nogo-A in human liver cancer cells. Reverse transcription polymerase chain reaction was used to detect the expression of Nogo-A in four liver cancer cell lines. A lentivirus vector was then constructed to mediate RNA interference (RNAi) targeting of Nogo-A (LV-Nogo-A-siRNA) and was confirmed to successfully suppress the expression of the Nogo-A gene in SMMC-7721 cells. Furthermore, Nogo-A was observed to be highly expressed in liver cancer cell lines. RNAi of Nogo-A using the LV-Nogo-A-siRNA construct significantly decreased Nogo-A protein expression and specifically inhibited the growth of SMMC-7721 cells. This growth inhibitory effect may be attributed to an increase in G2/M phase arrest and apoptosis in SMMC-7721 cells containing Nogo-A-siRNA. The results of this study demonstrate that Nogo-A may represent a novel therapeutic target for the treatment of liver cancer, in addition to its potent roles in neural systems.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2014.2050</identifier><identifier>PMID: 24626842</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Apoptosis ; Apoptosis - genetics ; Axonogenesis ; Carcinoma, Hepatocellular - genetics ; Cell cycle ; Cell Cycle Checkpoints - genetics ; Cell growth ; Cell Line, Tumor ; Cellular proteins ; Central nervous system ; Deoxyribonucleic acid ; Development and progression ; DNA ; Efficiency ; Endoplasmic reticulum ; Gene Deletion ; Gene Expression ; Gene Order ; Genetic aspects ; Genetic Vectors - genetics ; Hepatocellular carcinoma ; Hepatocytes ; Hepatoma ; Humans ; Infections ; lentivirus ; Lentivirus - genetics ; Liver cancer ; Liver Neoplasms - genetics ; myelin ; Myelin Proteins - genetics ; Nogo protein ; Nogo Proteins ; Nogo-A ; Plasmids ; Polymerase chain reaction ; Properties ; Proteins ; Reverse transcription ; RNA Interference ; RNA-mediated interference ; siRNA ; Tumor cell lines</subject><ispartof>Molecular medicine reports, 2014-05, Vol.9 (5), p.1743-1748</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-5798b32295f1d3c48c6e5f71a5c9ead4da8ae9595eaa8316a6670f82c494d9683</citedby><cites>FETCH-LOGICAL-c492t-5798b32295f1d3c48c6e5f71a5c9ead4da8ae9595eaa8316a6670f82c494d9683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,5571,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24626842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAO, CHUN-QIU</creatorcontrib><creatorcontrib>ZHOU, YUN</creatorcontrib><creatorcontrib>WANG, JIU-PING</creatorcontrib><creatorcontrib>PENG, MEI-JUN</creatorcontrib><creatorcontrib>XIE, YU-MEI</creatorcontrib><creatorcontrib>KANG, WEN-ZHEN</creatorcontrib><creatorcontrib>SUN, LI</creatorcontrib><creatorcontrib>WANG, PING-ZHONG</creatorcontrib><creatorcontrib>WAN, CHUN-LING</creatorcontrib><creatorcontrib>HE, LIN</creatorcontrib><creatorcontrib>CAI, LEI</creatorcontrib><creatorcontrib>JIA, ZHANG-SHENG</creatorcontrib><title>Role of Nogo-A in the regulation of hepatocellular carcinoma SMMC-7721 cell apoptosis</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Nogo-A has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. However, little is known about the role of Nogo-A in hepatocellular carcinoma (HCC), the most common primary malignant tumor with a high mortality rate. This study aimed to investigate the role of endogenous Nogo-A in human liver cancer cells. Reverse transcription polymerase chain reaction was used to detect the expression of Nogo-A in four liver cancer cell lines. A lentivirus vector was then constructed to mediate RNA interference (RNAi) targeting of Nogo-A (LV-Nogo-A-siRNA) and was confirmed to successfully suppress the expression of the Nogo-A gene in SMMC-7721 cells. Furthermore, Nogo-A was observed to be highly expressed in liver cancer cell lines. RNAi of Nogo-A using the LV-Nogo-A-siRNA construct significantly decreased Nogo-A protein expression and specifically inhibited the growth of SMMC-7721 cells. This growth inhibitory effect may be attributed to an increase in G2/M phase arrest and apoptosis in SMMC-7721 cells containing Nogo-A-siRNA. The results of this study demonstrate that Nogo-A may represent a novel therapeutic target for the treatment of liver cancer, in addition to its potent roles in neural systems.</description><subject>Apoptosis</subject><subject>Apoptosis - genetics</subject><subject>Axonogenesis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Cell cycle</subject><subject>Cell Cycle Checkpoints - genetics</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cellular proteins</subject><subject>Central nervous system</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Efficiency</subject><subject>Endoplasmic reticulum</subject><subject>Gene Deletion</subject><subject>Gene Expression</subject><subject>Gene Order</subject><subject>Genetic aspects</subject><subject>Genetic Vectors - genetics</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocytes</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Infections</subject><subject>lentivirus</subject><subject>Lentivirus - genetics</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>myelin</subject><subject>Myelin Proteins - genetics</subject><subject>Nogo protein</subject><subject>Nogo Proteins</subject><subject>Nogo-A</subject><subject>Plasmids</subject><subject>Polymerase chain reaction</subject><subject>Properties</subject><subject>Proteins</subject><subject>Reverse transcription</subject><subject>RNA Interference</subject><subject>RNA-mediated interference</subject><subject>siRNA</subject><subject>Tumor cell lines</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkUtr3DAUhUVoaR7tMtsi6KIrTfWWtRyGtA0kLTTJWtzI8kTBtlzJs8i_j8xMEwJFIF3u_c6RxEHonNGVaCz_Ngx5xSmTdVP0CJ0wYxkRlMp3h5pba47RaSmPlGrFlf2AjrnUXDeSn6C7P6kPOHX4V9omssZxxPNDwDlsdz3MMY3L7CFMMCcf-r42M_aQfRzTAPjm-npDjOEML0MMU5rmVGL5iN530Jfw6XCeobvvF7ebn-Tq94_LzfqKeGn5TJSxzb3g3KqOtcLLxuugOsNAeRuglS00EKyyKgA0gmnQ2tCu4VUtW6sbcYa-7H2nnP7uQpndY9rlsV7pmBXLL4XWr9QW-uDi2KU5gx9i8W4tmdLVSZpKrf5D1dWGIfo0hi7W_hsB2Qt8TqXk0LkpxwHyk2PULdm4mo1bsnFLNpX_fHjs7n4I7Qv9L4wKfN0DZYKxjW0qL0x1ItQSqggzUohnNWaTwA</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>HAO, CHUN-QIU</creator><creator>ZHOU, YUN</creator><creator>WANG, JIU-PING</creator><creator>PENG, MEI-JUN</creator><creator>XIE, YU-MEI</creator><creator>KANG, WEN-ZHEN</creator><creator>SUN, LI</creator><creator>WANG, PING-ZHONG</creator><creator>WAN, CHUN-LING</creator><creator>HE, LIN</creator><creator>CAI, LEI</creator><creator>JIA, ZHANG-SHENG</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140501</creationdate><title>Role of Nogo-A in the regulation of hepatocellular carcinoma SMMC-7721 cell apoptosis</title><author>HAO, CHUN-QIU ; ZHOU, YUN ; WANG, JIU-PING ; PENG, MEI-JUN ; XIE, YU-MEI ; KANG, WEN-ZHEN ; SUN, LI ; WANG, PING-ZHONG ; WAN, CHUN-LING ; HE, LIN ; CAI, LEI ; JIA, ZHANG-SHENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-5798b32295f1d3c48c6e5f71a5c9ead4da8ae9595eaa8316a6670f82c494d9683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Apoptosis</topic><topic>Apoptosis - genetics</topic><topic>Axonogenesis</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Cell cycle</topic><topic>Cell Cycle Checkpoints - genetics</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cellular proteins</topic><topic>Central nervous system</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Efficiency</topic><topic>Endoplasmic reticulum</topic><topic>Gene Deletion</topic><topic>Gene Expression</topic><topic>Gene Order</topic><topic>Genetic aspects</topic><topic>Genetic Vectors - genetics</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocytes</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Infections</topic><topic>lentivirus</topic><topic>Lentivirus - genetics</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>myelin</topic><topic>Myelin Proteins - genetics</topic><topic>Nogo protein</topic><topic>Nogo Proteins</topic><topic>Nogo-A</topic><topic>Plasmids</topic><topic>Polymerase chain reaction</topic><topic>Properties</topic><topic>Proteins</topic><topic>Reverse transcription</topic><topic>RNA Interference</topic><topic>RNA-mediated interference</topic><topic>siRNA</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAO, CHUN-QIU</creatorcontrib><creatorcontrib>ZHOU, YUN</creatorcontrib><creatorcontrib>WANG, JIU-PING</creatorcontrib><creatorcontrib>PENG, MEI-JUN</creatorcontrib><creatorcontrib>XIE, YU-MEI</creatorcontrib><creatorcontrib>KANG, WEN-ZHEN</creatorcontrib><creatorcontrib>SUN, LI</creatorcontrib><creatorcontrib>WANG, PING-ZHONG</creatorcontrib><creatorcontrib>WAN, CHUN-LING</creatorcontrib><creatorcontrib>HE, LIN</creatorcontrib><creatorcontrib>CAI, LEI</creatorcontrib><creatorcontrib>JIA, ZHANG-SHENG</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAO, CHUN-QIU</au><au>ZHOU, YUN</au><au>WANG, JIU-PING</au><au>PENG, MEI-JUN</au><au>XIE, YU-MEI</au><au>KANG, WEN-ZHEN</au><au>SUN, LI</au><au>WANG, PING-ZHONG</au><au>WAN, CHUN-LING</au><au>HE, LIN</au><au>CAI, LEI</au><au>JIA, ZHANG-SHENG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Nogo-A in the regulation of hepatocellular carcinoma SMMC-7721 cell apoptosis</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>1743</spage><epage>1748</epage><pages>1743-1748</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Nogo-A has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. However, little is known about the role of Nogo-A in hepatocellular carcinoma (HCC), the most common primary malignant tumor with a high mortality rate. This study aimed to investigate the role of endogenous Nogo-A in human liver cancer cells. Reverse transcription polymerase chain reaction was used to detect the expression of Nogo-A in four liver cancer cell lines. A lentivirus vector was then constructed to mediate RNA interference (RNAi) targeting of Nogo-A (LV-Nogo-A-siRNA) and was confirmed to successfully suppress the expression of the Nogo-A gene in SMMC-7721 cells. Furthermore, Nogo-A was observed to be highly expressed in liver cancer cell lines. RNAi of Nogo-A using the LV-Nogo-A-siRNA construct significantly decreased Nogo-A protein expression and specifically inhibited the growth of SMMC-7721 cells. This growth inhibitory effect may be attributed to an increase in G2/M phase arrest and apoptosis in SMMC-7721 cells containing Nogo-A-siRNA. The results of this study demonstrate that Nogo-A may represent a novel therapeutic target for the treatment of liver cancer, in addition to its potent roles in neural systems.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24626842</pmid><doi>10.3892/mmr.2014.2050</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Apoptosis Apoptosis - genetics Axonogenesis Carcinoma, Hepatocellular - genetics Cell cycle Cell Cycle Checkpoints - genetics Cell growth Cell Line, Tumor Cellular proteins Central nervous system Deoxyribonucleic acid Development and progression DNA Efficiency Endoplasmic reticulum Gene Deletion Gene Expression Gene Order Genetic aspects Genetic Vectors - genetics Hepatocellular carcinoma Hepatocytes Hepatoma Humans Infections lentivirus Lentivirus - genetics Liver cancer Liver Neoplasms - genetics myelin Myelin Proteins - genetics Nogo protein Nogo Proteins Nogo-A Plasmids Polymerase chain reaction Properties Proteins Reverse transcription RNA Interference RNA-mediated interference siRNA Tumor cell lines |
| title | Role of Nogo-A in the regulation of hepatocellular carcinoma SMMC-7721 cell apoptosis |
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