Transforming growth factor-1 promotes the transcriptional activation of plasminogen activator inhibitor type 1 in carcinoma-associated fibroblasts

Carcinoma-associated fibroblasts (CAFs) play a pivotal role in promoting the growth, invasion and metastasis of tumor cells. However, to date little is known about the oncogenic mechanisms of CAFs. This study aimed to identify the microenvironmental factors involved in tumor development and progress...

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Veröffentlicht in:	Molecular medicine reports 2012-11, Vol.6 (5), p.1001-1005
Hauptverfasser:	ZHU, YU, YIN, WAN-LE, BA, YU-FENG, TIAN, LIN, GU, ZHI-QIANG, ZHANG, MING-SHENG, ZHONG, CHU-NAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Angiogenesis Bone marrow Carcinoma - metabolism Carcinoma - pathology carcinoma-associated fibroblasts CD90 antigen Cells, Cultured Cloning Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Enzyme-linked immunosorbent assay Epidermal growth factor Epidermal Growth Factor - pharmacology Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene expression Growth factors Humans Hybridization Liver Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Medical prognosis Metastases Metastasis Northern blotting Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism plasminogen activator inhibitor type 1 Plasminogen activator inhibitors Platelet-derived growth factor Platelet-Derived Growth Factor - pharmacology RNA, Messenger - metabolism Smooth muscle Thy-1 Antigens - metabolism Transcription activation Transcriptional Activation Transforming growth factor Transforming Growth Factor beta1 - pharmacology transforming growth factor-1 tumor Tumor cells Tumor necrosis factor Tumors Up-Regulation - drug effects
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